http://smartech.gatech.edu/handle/1853/27185 The heart of Georgia Tech's thriving life sciences community Search the Channel search http://smartech.gatech.edu/simple-search http://smartech.gatech.edu/handle/1853/31225 Title: EGFR Family Gymnastics <br/> <br/>Authors: Griffith, Linda G. <br/> <br/>Description: Linda G. Griffith, Professor of Biological Engineering and Mechanical Engineering, Director, Biotechnology Process Engineering Center at the Massachusetts Institute of Technology presented a lecture on October 22, 2009 at 11:00 am in the Suddath Seminar Room, IBB Building, Georgia Tech Campus. Wed, 21 Oct 2009 22:58:59 GMT http://smartech.gatech.edu/handle/1853/31171 Title: Smart Biomaterials Inspired by Nature's Mechanisms <br/> <br/>Authors: Murphy, William L. <br/> <br/>Abstract: Control over the soluble signals that cells encounter in their local environment is a common theme in natural tissue formation, and also an emerging theme in functional tissue engineering strategies. This concept is particularly important in stem cell-based applications, in which local soluble signals can dictate cell fate decisions. Therefore, there is significant interest in using bioengineering approaches to control soluble signaling in the stem cell microenvironment. Nature often achieves intricate control over local soluble signaling via specific, non-covalent interactions. Inspired by these natural interactions, we are interested in creating biomaterials that actively regulate soluble signaling. For example, our recent studies have used engineered protein-peptide and protein-mineral interactions to build new classes of materials that are bio-responsive and capable of regulating growth factor signaling. This talk will specifically highlight bio-inspired protein conformational shifts and engineered growth factor sequestering as mechanisms to regulate stem cell behavior upon and within biomaterials. <br/> <br/>Description: William L. Murphy of the University of Wisconsin presented a lecture on October 29, 2009 at 11:00 am in the Suddath Seminar Room, IBB Building, Georgia Tech Campus. Wed, 28 Oct 2009 22:58:59 GMT http://smartech.gatech.edu/handle/1853/30612 Title: New Biology and Biotechnology <br/> <br/>Authors: Sharp, Phillip A. <br/> <br/>Description: Phil Sharp, PhD, from MIT gave a brief presentation to the Friends of the Petit Institute Group on October 2, 2009 in IBB Seminar Room 1128. Thu, 01 Oct 2009 22:58:59 GMT http://smartech.gatech.edu/handle/1853/30578 Title: The Biology and Therapeutic Promise of Small RNAs <br/> <br/>Authors: Sharp, Phillip A. <br/> <br/>Abstract: The discovery of the multiple roles of small RNAs in regulation of gene expression is a revolutionary advance in biology. MicroRNAs probably interact with mRNAs from half of all human genes. Overexpression of some microRNAs is associated with certain types of cancer while, more commonly, a reduction in microRNA levels is seen in tumors. Recent evidence suggests that the primary role of microRNAs might be to provide robustness or stability to systems. We have recently found that cytoplasmic subcellular localization of mRNAs and microRNAs is dependent upon formation of poly(ADP-ribose) and that microRNA repression is reduced under stress conditions. <br/> <br/>Description: Presented by Phillip A. Sharp, PhD., Institute Professor at the Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology on October 2, 2009 11:00 am – 12:30 pm in the IBB Atrium on the Georgia Tech campus. Thu, 01 Oct 2009 22:58:59 GMT