Voit et al., In Silico Biol. 5, 0010 (2004); Figure 2

Figure 2: According to conventional wisdom of modeling linear pathways, in which X1 is converted into X2 and then X3, the equation for X3 does not include X1, because its effect is indirect. Nonetheless, X1 does affect X3, as is shown in the time courses (a) and the phase-plane plots on the right-hand side (b and c). The effect of X1 (c) has entirely different characteristics than that exerted by X2 (b) and is somewhat less pronounced. (Numerical model used for this example: At time t = 0.1, X1 is externally set to 0.05.)

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