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>> Ramani everyone welcome to nano fans Robyn our series this is our 2nd very in our By the end rest she'll be talking about pediatric and point of care technology at George attack. And as I said scenic. Is the one that hosts are now on offense will be in our series scenic stands for Southeastern.

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Readers knowing at their peril and characterization and scenic is one among the 16. Sites among the national program of national nanotechnology quantitative infrastructure which is supported by National Science Foundation the goal for this program is to open up you know us it is infrastructure capabilities to off campus researchers both coming from academia as well as industry but before I formally introduce Leon West enjoyed his a.b. about any program.

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The Southeastern nanotechnology infrastructure corridor or scenic is a partnership between the Georgia Tech Institute for electronics and nanotechnology and the joint school of nano science and nano engineering an academic collaboration between North Carolina State University and the University of North Carolina at Greensboro scenic is a part of the n.s.f. funded national nanotechnology coordinated infrastructure a network of 16 academic centers and their partners that provide open access to state of the art fabrication and characterization facilities and stuff expertise across the u.s. this network also supports education and outreach programs as well as societal unethical implications and nanotechnology activities cynic as just researchers from academia industry and government labs with their micro nano fabrication and characterization projects scenic users who work in areas such as electronics.

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Sensors biomaterials that Sonic's and materials growth and synthesis our facilities can also meet the unique needs of nontraditional researchers from disciplines such as Life Sciences biomedical engineering and healthcare it also offers short courses hands on learning experiences in micro fabrication software and characterization techniques more than 1300 researchers use our facilities annually training is available for users who are not members of the joint school of nano science and now know engineering or Georgia Tech communities to access the tools they need seen it also enables remote work allowing researchers to send samples for processing or analysis experienced scenic offers broad capabilities in e.b.m. lithography.

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Film deposition processing metal ization packaged. Microcell printing imaging spectroscopy. Microanalysis add a little chemistry material testing laser micro machining and computation for more information on cynically so it is check out our website at scenic Ga Tech dot edu so feel free to take time to visit our website to know more about scenic program at the scenic dark addict r.t.t. you with that said it's a pleasure to welcome you and best to talk to our national friends or an audience of Esther's a principal research scientist and the chief engineer of pediatric technology at the Georgia Tech her research includes remote sensing sensor development and mobile health applications she is also the president of the International Children's advice and a network a nonprofit that promotes the pediatric patient wise in health care research and innovation he sits on the board of the Georgia technology authority and hope for Hendry is on the executive leadership team of the International Society for pediatric innovation and is also a member of the extra technical advisory committee for the pediatric trial network so with that said let's invite you to speak on her topic really African point of care technology at Georgia Tech b.n. Welcome thank you Aaron.

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Thank you Paul for the energy action and I'm excited to help out here such a day I'm going to talk about pediatric technologies and point of care technologies at Georgia Tech and some initiatives that are going on that you might be interested in. I am mostly presenting on other people's work so work around campus if you haven't got may or may not be able to answer but I can always put you in touch with the right person to get more information yes I want to talk to you today about different things that we have going on at Georgia Tech in the area pediatrics and point of care technologies so I thought I would just start by set talking about.

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Some of the hospitals that we have close relationships with so Children's Healthcare of Atlanta obviously our most of our. Programs and pediatrics are with Children's Healthcare of Atlanta and they are great local partner we also work with trying to hospitals who has 20 different hospitals around the u.s. and then 21 in Canada and one in Mexico and we're just starting that relationship but they've already funded a lot of different research around campus and we also have a relationship with Children's National in d.c. And right now we have projects with their emergency department and then we're also requote working really closely with Children's Hospital of Orange County.

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And that relationship as far as project work is going it's based in data analytics. And I thought I would just say that here's an example of some of the different areas of technology that we cooperate in with these hospitals but there's so much more to it than that so it's really anything any area of interest across campus is open for a relationship with one of these hospitals that work on a project together and that's what I do day to day so I will play the technical liaison between when actions at various hospitals and people at Georgia Tech and I also you'll see here in the bottom right corner the petite Scholars program that's an undergraduate research program offered in the Institute for Bioengineering in bio science we work with student groups across campus so not only protect scholars but capstone regular classes whatever it might be that might want to have some real world projects or their classes the other thing we really perks on as we want to solve clinician driven problems that's not that somebody in Georgia Tech has a cool technology we want to see how to make it fit somewhere else it's that a clinician has a problem and I pick the people at Georgia Tech with the right technologies and experience to create the solutions to the problems and that's really important that's very different than most and most ways that research works at this point so we want to make sure that we're answering a real world problem like this so you can look at the screen and it is a mess to try to imagine being a doctor I mean you can barely see the baby in this picture because everything else is just surrounding it and shapes and everything.

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Being You can see where there's a little circle there and that's one of the screens that tells you the vital signs of this child. And it's just it's hard for doctors to focus and see the information clearly and understand what's going on so we put a researcher on campus together with a doctor Children's Healthcare Atlanta and they have come up with this.

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Bio patch bio sensor and you can say down below it says e.k.g. respiration motion temperature and how the child is breathing can all be measured with that one little at he said patch that goes on the child. The information can be sent to the doctor and it replicates what you would say on that screen that you could barely see in that picture and the significance of this work is that it was looking for readiness for transfer to looking at a child in the i.c.u. and determining from it's information that you can see on the on that screen whether or not the child is ready to be transferred out of the i.c.u. or ready to be sent home and so what this does is it really gives doctors a knowledge that it's Ok to move the child out because sometimes right now they think the child's doing well and they move the child out but then it has to come right back to i.c.u. and with this program that they've developed this sensor technology and analytics they have been able to successfully determine when the child should leave to avoid the child coming back again and also acts as an early warning sign for any kind of crash or immediate emergency need the child might have so they can get to it before something really bad happens.

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There's another one I've infiltration so. Here you can see the pictures on the on the right are really horrible you can see what kind of damage can be caused by the infiltration which is where and when you're giving a child an i.v. if the i.v.. Liquid goes into the skin as opposed to into the vein like it's supposed to and that can be because you miss it or you break through the vein or the vein bursts and.

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Then you can have these bad things happen here on the right and you can see that that would cause permanent scarring and permanent damage for the child for the life of the child this condition also happens in adults and particularly older adults and if you recall recall back to the pretty by a patch that I just showed you a couple of slides ago that's what the solution here is meant to look like in the end though right now what we're planning is a flexible miniature electronics to go into the dressing that goes around the i.v. site.

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To determine whether or not the i.v. has broken through the vein or not and right now we have a study in place at Children's Healthcare Atlanta it's a little bit big and bulky right now but again the goal is to make it miniature like you saw a couple of slides ago and they told us.

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Right now to detect this nurses have to go around individually to each child every 30 minutes and check to see if something's happening. And they do it by feel and looking at the hand the swelling of the hand touch does it feel squishy more unusual and they just can't get around to it as often as they need to which is when the bad things happen and so they told us if we could detect the i.v. infiltration within 30 minutes.

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That would make a huge difference for them because it would be the difference between taking care of the problem immediately with no long term damage versus what you saw a slide ago and. We are really excited about it because the initial data we've taken with pigs and the.

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And it has that we did with with animals so that we think we can get it detected within 2 minutes so we're really excited about that but again we're starting a trial at Children's just to take some data and make sure what we saw in pigs looks like what we see and humans and we have to get kids enrolled pivot has played a little bit of a damper role there but it's coming along now so that's good Another one is sound as a biomarker for juvenile arthritis and so these are kids who have joint problems like adults with arthritis.

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And the joints are really act like they should they're very painful and we have a researcher on campus who has figured out he can place audio sensors on the knee or the joint and he can actually hear the difference between a healthy joint and. One that's having problems and you can see on the data and the graph there that the kids who were either did not have arthritis or had been through treatment for the arthritis to make it better.

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That it was very different the way it sounded was very different than the way it sounds for kids with juvenile arthritis in their read their. And so what we hope is that today doctors can use this in the clinic to listen to the Navy and see if it's ready to go to get back to sports or something like that after injury after it's been treated another very cool technology we have on campus so a lot of 3 d. printing these days people like 3 d. printing.

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So we have a professor on campus who has created a stent for when a child has a collapsed trachea and so on the left and the yellow circle you'll see a pinched area and the trachea and that's where the problem is for the child so a child with this issue cannot breathe on their own and they have to be hooked up to life support the tracheal splint you can see on the to right hand pictures in the red box you can see where what they can do now with what this researcher on campus developed is to a customs plant based on the m.r.i. of the child and they can do an operation to put it in place to save the child because also with these kids with class tracheas they really can't live on their own.

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And so the child usually dies. But with this one the child and lead and it's really amazing so we've done our 6th. Child and the world with this treatment this does not happen often and the 1st one in Georgia happened last spring I think and you can see the baby here and everything that he set up too and then you get to see the picture on the right with the mother holding the child so it's 4 months old after this treatment that was the 1st time that this mother got to hold her child she had not been able to do before that because everything that this child was hooked up to so I think that that's really amazing and anyone out there has a parent can imagine what that was like for that mother and that moment.

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Another technology that's been developed at Georgia Tech is something called hygiene or by a scrub and this one is one of those things that it's so obvious and so simple that you just are kind of like I can't believe nobody thought of this before though. One of the biggest problems and health care is central line infections meaning that where these connectors are so you can see the big red arrow.

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Pointing to something in the middle of the screen that's the hub that needs to be claimed and it gets cleaned every time the nurse comes in and changes out the i.v. bag for the patient and so this is often right now in the world they use something like a little.

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Towel that that you might get at a restaurant wash your hands you know and wipe their fingers off with and you can imagine that that does not get into all the crevices of the home and so we have somebody on campus who created a little squishy something that looks like a.

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Sugar cube and to claim that to clean the house and it's such an alcohol and so you can imagine that that actually allows the alcohol to really get through anywhere on the connection and so at the bottom you can see the petri dishes and the 1st column that are covered are the control so there is nothing there stopping the.

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Growth of the infection the center one is when you use a little more to tell that and you can see that there's still a lot of bacteria there and then on the right side you say regimes that have hygiene. Here and you can see that that really does get rid of almost all of what the infection would be if the potential risk for infection would be for that the patient.

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There's another technology working on and I think this one is really fascinating So this is for a robotic brain surgery it's a robotic Lee controlled or it's a controlled or a robot that you can see above the corner so you can see that it's really really tiny and you can make that had been really any direction you want to so right now when you have surgery you go in through a hole that would be drilled in skull like you can see in the top and right now what they have instead of something that spendable is just straight So think of like a straw or something like that and if they wanted to go in and remove a tumor in the brain they would put the straw and but then they would have to like move it around and a cone shape so you get collateral damage of the brain and that whole area with the white triangle you can kind of see what the collateral damage would be that would represent a cone shape within the person's had the red being the chamber they're trying to get out and then on the right you can put that same straw and but instead of having to move the whole straw around in creating all that damage to the brain they can really control the tap and just reach where the tumor has and then they can pull everything straight back out so there's there's the potential for this to be really life changing for any child who has to have or any person who has to have.

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Brain surgery where they have to remove a tumor that's more embedded in the brain we're also working on lots of things like exoskeleton So here's another one robotic controlled. Glove essentially you can wear this is for kids who have suffered. And my gosh paralyzation sorry this is for child his self will suffer from paralyzation of of some sort that has made them unable to use their hands but with this love that they can put on that's being worked on this can help the child.

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Move the fingers when they can't do it on their own and this work is being done with Shriners hospitals. There were also doing lower extremity exoskeletons again something else that's being done with Shriners Hospitals there for kids with cerebral palsy they are unable to walk very easily on their own but this excess skeleton that's being developed is actually allowing children to.

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Walk better on their own it understands from the step what. What the muscle movement should be that they don't have and the robot actually helps them move the foot so that they get the right force and the stress and the type of step they're trying to take we also have a center for Medicaid and Medicare data.

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Resources we have the last I want to say about 10 years now that are available for all 50 states are able to do some really interesting studies with that data and here was an interesting one said they were looking at kids with asthma and they figured out that kids who were part of the 20 miles away from an asthma specialist had much worse outcomes in asthma it's much more severe they use the emergency department more often and so what that was doing is that was helping Children's Healthcare of Atlanta determined where the.

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Where they might want to put their next emergency care here we have an analysis tool for. For kids with. Autism so very severe behavior kids they were trying to do with these kids to do studies with them but they're so if you're a prosecutor that we had to create a database that could be shared with every center all 7 centers across the country who work with us.

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So that the data could be shared and studies could be done on that larger population since the population overall assessment there's another one but this is a technology that has been turned into a company sanguine as a company it comes out of Georgia Tech and it's to help determine your anemia level and it does require blood pressure but what it does is it puts your blood drop into a little container that you can say and you measure the color of the container with this little card that you get and they're trying to automate this now for you actually to determine what your anemia level as and so for countries that maybe don't have is going to accesses the u.s. right now this is one is really important it can also be done at home which is really important in the u.s. And so it's been a really interesting great technology that again is already out there and the public another one another part of the same going to offering is taking a picture of your nail bad your nail that does not have melanin in it and so no matter what your skin color is if you can take a picture of your nail that they have figured out how to determine what your anemia level is with yourself and know fingerprint needed and so you can imagine how wonderful this will be for anyone who has to do fingerprints often to determine what their anemia level is it's also much faster as you can imagine just being able to take it picture with yourself and it tells you instantaneously.

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Another product that has come to market from something being done at Georgia Tech and this was really on in the mobile health base they a faculty member made a little slide on and it looks a little better than this now not quite so clunky. That has the tool tip that allows the doctor to look inside your ear as you can see with this child and the clinician right here however it's meant for home use so for parents with kids with air infections that happen all the time you know what it is the kid knows what it is your doctor knows what it is but you still have to go in and have them see it and they write your prescription with this technology you can take the picture from home it automatically exams and in focus has been subject your to your doctor and then they can make a diagnosis from a remote location to give you the antibiotics so it saves time for the patient and the parent and the doctor for you to just be able to do it this way instead another app to spend developed and is on the market right now it's called your app and it's for kids with messed up your products syndrome so what these children have to do is monitor protein and their urine multiple times a day every day and right now they're doing it on your instructor then they have to figure out you know what what shade what color as and it's just a little bit more difficult for them to do should always determine what level it really is and then in addition to that they have to make a list by hand write down what they've been doing and what they've been saying and what their results have been and what this app it takes a picture of the stick it automatically determines from any year and strip and here and strip.

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What the level actually is and then it will also record those results for you every time you take it so that you have something to take to the doctor to. To help him better understand where you are and that will help with the overall goal of what the doctor is trying to achieve with that with the child.

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We have another one for central management and this is for kids of color rectal issues so when I was 1st introduced to this problem these are children who cannot control their bowel. At all and it's really really horrible for these kids you can imagine what kind of. Pressure and stress and anxiety that puts on a child with all the other kids knowing you have this kind of problem truly when it was presented to me I mean I cried because it was just horrible to hear about and we have a group that is trying to help these kids better manage their symptoms and with better management they get better control and so less accidents and they were doing this with high school kids and so they knew that it was something a little bit embarrassing they built something that is really nondescript it's not a game or anything like that that you might want to build with a younger child.

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And it's something that they can just with a couple of clicks of the button indicate what's happened and move on from there and so hopefully it's a little bit more discreet way for these kids to be able to control their symptoms and have a little bit better life moving forward if they can better keep things from happening dating disorders This is another problem there are some kids out there who would literally just not eat and it's not that they're just a picky eater it's literally that they take nothing by mouth and that usually stems from some sort of condition they've had in earlier in life that gave them a negative association with food for whatever reason.

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And so what we did with this group was we built a tool that allows a clinician to talk through kind of a a decision support tool so what the clinician figured out and I think this is also staggering is that. He figured out what these 5 bite sessions.

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Where he would give a child spoonful of food whether it had chewed on it or not or a straight or regular shared based on how the child reacted to the food whether they spotted it away where they spit it out whether they kept it in their mouth or didn't didn't spit out that wouldn't follow whether they just voiced an opinion he figured out from their reactions how to actually talk kids through into eating again so they don't have to be on feeding tubes and.

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He was really the only person who could do this recall because it was in his head he was starting to write it down and share it with other clinicians for them to be able to do the process themselves. But we took that and put it into an app and so now what that was does is it allows the data to be.

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Answered rapidly as to where the child is in the feeding because for 4 they were taking all this information by hand and doing a calculation later so they're getting instantaneous results and it talks them through the protocol so they don't have to flip through a sack literally an inch thick of paper.

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As to where they need to go next and so the thought here is is that now instead of just making it possible for more clinicians to give time to the child. They can now send the at home with the parents and so after an initial diagnosis maybe they only have to come back and one or 2 more times during the course of the treatment as opposed to every day multiple times a day which you can imagine most kids with about half the kids or kids with autism you're interrupting a routine the parents having to take off for the kids having to take off school and some of these kids are early school age maybe 1st grade and it's really not ideal for them to have to do that so if they can do that at home it's really life changing and so.

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This really changed the way the clinician was thinking about giving care so it wasn't just we turned your protocol and shown apa to make it easier for you in the clinic it's a new way of thinking about doing that's a new way to do it that's really going to benefit the kids in the parents who have this issue.

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Another one is another app called designing cancer care for kids by kids this is at the athletic Cancer Center what this did was really trying to figure out where in the process of a multi hour visit that kids with cancer come in. Where in the process they're having the most anxiety and also where in the process could they speed things up to where the kid doesn't get stuck in certain places and so they started with a paper version where they took data to try to figure out what was going on they made a map of the visits that child a child goes through while they're there at their cancer treatment visit and they figured out one where they could save some time which is good but they also figured out where these kids were experiencing the most anxiety and it turned out were these kids were in a waiting room for like 30 minutes of the post just going back for the treatment that was actually giving kids more anxiety than just being in the original waiting room and being called back for a treatment and so this app is really helping the clinicians figure out it's a real time advocate can play with throughout their visit.

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It's got games and it is distraction and things like that but it's also keeping track periodic play of how the kid is feeling so that if there is a child who is really experiencing some anxiety during their visit the clinic the clinicians will be alerted and they can go help and be with that child and help take some actions to reduce anxiety for that kid.

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And so here I'm talking about a couple other things and some close to being done. But here I'm talking about a couple of things going on around campus that are new and they're resources available at Georgia Tech and beyond Georgia Tech. And one of them is called the innovation catalyst and the innovation catalyst is really looking at making health care technologies bored with commercialization resource resources and so if you're somebody with an early stage.

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Product then this might be a group that you want to interact with to help bring your technology forward. And so some of the different things that go on through the innovation catalyst are the at hatchery biz grants and bench to market talks and also road mapping and venture funding and then the innovation trail head and so again these are all things that want to help take your product forward.

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Whether it's through the at hatchery of which I think at least one of the ones that I mentioned earlier has gone through the ACA tree I think that the anemia the anemia was sanguine. They also work with Capstone students and be any students and so I think that it's a really.

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Interesting and valuable thing that Georgia Tech has to be able to do this now with our faculty and our students. And one of the things that they're working on right now is this one called serve and so this is to improve outcomes for victims of interpersonal violence and it's really something to kind of help them.

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Keep track of what's going on but it sends them reinforcing reinforcing positive behaviors that they can do to other support resources for the patient patient the person who is needing this this at to help. Reject reducing e.r. visits by improving pain management and some of the things that go on.

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Maybe in the home medication compliance. Also wound care education increased follow up visit attendance as one of their goals and so it's really something to help positively. Affect the patient to help them do better with. Injuries that they receive another one that they're doing right now is called hometown.

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This is for. People with cancer certain types of cancer or predisposition to cancer and so you may have the bracket gene one of the wreckage aims for example and if you do this would be an app that you would use and it would help you keep track of things that are going on kind of remind you when to do things with self management.

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Might give you help you understand what are symptoms early on so you can do early detection and then also increase the compliance that you have with doing early detection and monitoring the work that you have at home so it's really to help people with cancer predispositions watch for things so ultimately the goal would be that you would catch cancer earlier and then get better outcomes for these patients with cancer.

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I didn't know this was one of these kind of slides but. Another product program that's going on in campus that we won an award recently for is something called Rad x. and this is important and the. Source to help do a diagnostic for covert ads so something big obviously that we're all interested in right now you know there's a lot of going on at Georgia Tech with kind of it and this is money that we got in from and I age and I want to say it was on the order of like $30000000.00 to help do research there to speed up the process.

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For things associated diagnosis the city stated with. SARS and yams can bring all this forward so what we want to do with this is. Look at point of care home based and community get based device says what they want to do is they want to say look and so having to come in somewhere and get the test and risk being exposed to more people can we do this at home can we do it more rapidly as you get results there we think that in the long run cover testing is really going to move towards the home as opposed to having to go into the clinic and that's going to be better for everyone as far as you infecting people if you do have it or be infected by people if you maybe didn't have if you had to go into an area.

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A doctor's office where there might be several patients around and I know that's not my last slide that for some reason it's not advancing. So I was almost done here anyway I only have like 2 more slides. So we can leave it with this set radix radix is being and also the the innovation program that I just manager mentioned are both being run by Wilbur Lam on campus he is a pediatrician at Children's Healthcare of Atlanta he also is in a biomedical engineering program and works out of a lab at Georgia Tech with Georgia Tech students and so he would be the one to talk to about either one of these programs.

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He also has done several of the other projects that I mentioned previously and the talk and so he is a great resource on campus to help with anything like this essentially my last slide was going to say is just that if you have an idea on campus at anything in the health care space or you're joining something that you think could be applied to health care please reach out to me I'm happy to put you in touch with anyone that you can that you might want to be in touch with.

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To help move that i.g.s. forward I also regularly talk to people across campus so that I can learn what you're doing and if I understand what you're doing I'm better able to help make matches with clinicians who have ideas that might be able to utilize your technology so it's really if you have anything please feel free to reach out my information it's Al West at Ga Tech Ga t.c.h. dot edu and Paul could definitely give you the information after this program.

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And so really right now I'd love to take any questions you might have. Thank you young for your presentation well really appreciate your real ability to come over here and. These are great programs and and it's very important for non-fans are instant all about all these resources available on campus and yet there are so many resources on campus Yes Thanks again for making yourself available it's time for questions I see a couple of questions and I'll be glad to read those questions for you.

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It's the. Present day isn't presentations will be able to guess once it's edited by g.-d. lever read will be posted in our scenic website you can revisit after we go Szell and otherwise it's it would say thank you that was really interesting and this another thank you note for mozzies doctor saying thank you notes here sounds like a.

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Lot of information you offered and so I think. You know in the abstract bio that we we have in the link you can find Leon Best contact information still feel free to connect with her directly. There's another question is would it be possible to get in touch with one of the winners of the project if so how absolutely just reach out to me and I'll put you in touch with the person who's doing it but if you have one in particular you're interested in I might be able to just tell you which one is it.

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You may not be able to answer that right away but. If you want to see if you want to type which program you are interested in. Then I would be glad to supply that for your email to Leon as well so yeah. And I think one of the big takeaways here is that clinicians have really big problems and something that might seem really simple to an engineer to fix has maybe been plaguing that condition for a long time and just that connection between the engineering the clinician can really change the way that everything is done and just make it better for everyone involved you know as he's talking about it's the 1st program you mention I believe wasn't a catalyst.

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The very 1st one I mentioned. What my slides are changing out here will be with the 1st one was that I mentioned it stopped. It smart package The bite Yeah the bio patch so that is. Pong Yeah. And if you don't know I'm on campus already again just reach out to me and I will definitely make an introduction there this is one that we're super super excited about because it's really just moves so far and such a very short time and it will really change the way some of these kids are hooked up to everything and allow at home monitoring as well.

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Thank you Doro and have goal and then I don't know that I'm no questions let's thank. You and one more time and. Thank you thank you everyone for joining and have a great day unfortunately you had not be able to log you in person so what you liked and in I like the virtual applause it was great.

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Thank you Mary right this is fantastic again happy to help in any way possible to make connections with any ethical or clinician anyone across campus and happy to learn about your technology and what you have going on in your lab well so I can make connections in the future for you sharpest Thank you everyone have a great day.