Now showing items 1-13 of 13

    • Development and clinical translation of microneedles for insulin delivery and self-vaccination 

      Norman, James Jefferis (Georgia Institute of Technology, 2012-12)
      Type-1 diabetes and influenza cause significant illness and unnecessary medical costs despite the existence of insulin for maintenance of diabetes and a vaccine for prevention of influenza. This dissertation describes three ...
    • Dissolving microneedles for cutaneous drug and vaccine delivery 

      Chu, Leonard Yi (Georgia Institute of Technology, 2009-11-10)
      Currently, biopharmaceuticals including vaccines, proteins, and DNA are delivered almost exclusively through the parenteral route using hypodermic needles. However, injection by hypodermic needles generates pain and causes ...
    • Dissolving Microneedles for Transdermal Drug Delivery 

      Lee, Jeong Woo (Georgia Institute of Technology, 2008-10-22)
      Microfabrication technology has been adapted to produce micron- scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines. This study presents a ...
    • Drug Eluting Nanoelectrode Array 

      Mattix, Brandon (Georgia Institute of Technology, 2010-08)
      In drug delivery, microneedles offer many unique characteristics which can improve the delivery of drugs into delicate tissues and tissue systems. These needles can be fabricated from a variety of materials including metals, ...
    • Drugs Are Only Skin Deep 

      Ludovice, Peter J.; Prausnitz, Mark (Georgia Institute of Technology, 2012-09-19)
      OK, they're more than skin deep, but delivery of drugs through the skin is a rapidly growing approach to drug delivery. Mark Prausnitz, from the School of Chemical & Biomolecular Engineering at Georgia Tech will join us ...
    • An Electrically Active Microneedle Electroporation Array for Intracellular Delivery of Biomolecules 

      Choi, Seong-O (Georgia Institute of Technology, 2007-11-14)
      The objective of this research is the development of an electrically active microneedle array that can deliver biomolecules such as DNA and drugs to epidermal cells by means of electroporation. Properly metallized microneedles ...
    • Fabrication and analysis of injection molded plastic microneedle arrays 

      Hamilton, Jordan David (Georgia Institute of Technology, 2011-01-24)
      This thesis describes the fabrication of plastic microneedle devices, their fabrication by injection molding, and analysis of the penetration mechanics. Injection molding is an economical mass-production technique that may ...
    • Laboratory for Drug Delivery 

      Prausnitz, Mark (Georgia Institute of Technology, 2009-06-05)
    • Medical Micro- and Nano-Technology: Case Studies in Transdermal Drug Delivery 

      Prausnitz, Mark (Georgia Institute of Technology, 2008-03-14)
    • Microneedles for transdermal drug delivery in human subjects 

      Gupta, Jyoti (Georgia Institute of Technology, 2009-07-06)
      Microneedles have been developed as a minimally invasive alternative to painful hypodermic needles to deliver modern biotherapeutics. Previously, several in-vitro and in-vivo animal studies have been conducted to show ...
    • Ocular drug delivery using microneedles 

      Jiang, Ninghao (Georgia Institute of Technology, 2006-11-21)
      Traditional methods of drug delivery to the eye include topical application, intraocular injection and systemic administration; however, each method has its limitation to efficiently delivery drugs to the back of the eye. ...
    • Polymer microneedles for transdermal delivery of biopharmaceuticals 

      Sullivan, Sean Padraic (Georgia Institute of Technology, 2009-02-03)
      Biopharmaceuticals, including proteins, DNA and vaccines, are one of the fastest growing segments of the overall pharmaceutical market. While the hypodermic injection, the most common delivery method for these molecules, ...
    • A Three-Dimensional Coupled Microelectrode and Microfluidic Array for Neuronal Interfacing 

      Choi, Yoonsu (Georgia Institute of Technology, 2005-05-20)
      The objective of this research is to develop a three-dimensional (3-D) microfluidic/ electronic interface system for sustaining and monitoring 3-D neuronal networks. This research work is divided into two parts. One is ...