Now showing items 1-20 of 227

    • AAV recombineering with single strand oligonucleotides 

      Hirsch, Matthew L.; Storici, Francesca; Li, Chengwen; Choi, Vivian W.; Samulski, R. Jude (Georgia Institute of TechnologyPublic Library of Science, 2009-11)
      Adeno-associated virus (AAV) transduction initiates a signaling cascade that culminates in a transient DNA damage response. During this time, host DNA repair proteins convert the linear single-strand AAV genomes to ...
    • Activated chemical defenses in tropical versus temperate seaweeds 

      Cetrulo, Giancarlo L.; Hay, Mark E. (Georgia Institute of TechnologyInter-Research, 2000-11-22)
      Chemical defenses that are rapidly activated in response to injury have been reported in numerous species of vascular plants, but activated chemical defense has been demonstrated for only 1 genus of seaweed. To investigate ...
    • Adaptive Evolution of Phytoplankton Cell Size 

      Jiang, Lin; Schofield, Oscar M. E.; Falkowski, Paul G. (Georgia Institute of TechnologyUniversity of Chicago Press, 2005-10)
      We present a simple nutrient‐phytoplankton‐zooplankton (NPZ) model that incorporates adaptive evolution and allometric relations to examine the patterns and consequences of adaptive changes in plankton body size. Assuming ...
    • Ambiguous role of phlorotannins as chemical defenses in the brown alga Fucus vesiculosus 

      Kubanek, Julia; Lester, Sarah E.; Fenical, William; Hay, Mark E. (Georgia Institute of TechnologyInter-Research, 2004-08-16)
      Brown seaweeds (Fucales) produce phlorotannins that are often considered chemical defenses against herbivores. The many correlative and fewer direct tests conducted have shown effects of phlorotannins on herbivore feeding ...
    • Amphipods are not all created equal: a reply to Bell 

      Duffy, J. Emmett; Hay, Mark E. (Georgia Institute of TechnologyEcological Society of America, 1991)
      In laboratory feeding trials, Hay et al. (1987) found that the tube-building amphipod Ampithoe longimana readily consumed the brown seaweed Dictyota dichotorna, which was not eaten by local fish. The diterpene alcohols ...
    • Analysis of transitions at two-fold redundant sites in mammalian genomes. Transition redundant approach-to-equilibrium (TREx) distance metrics 

      Li, Tang; Chamberlin, Stephen G.; Caraco, M. Daniel; Liberles, David A.; Gaucher, Eric A.; Benner, Steven A. (Georgia Institute of TechnologyBioMed Central, 2006-03-20)
      Background: The exchange of nucleotides at synonymous sites in a gene encoding a protein is believed to have little impact on the fitness of a host organism. This should be especially true for synonymous transitions, where ...
    • An Ancient Gene Network Is Co-opted for Teeth on Old and New Jaws 

      Fraser, Gareth J.; Hulsey, C. Darrin; Bloomquist, Ryan F.; Uyesugi, Kristine; Manley, Nancy R.; Streelman, J. Todd (Georgia Institute of TechnologyPublic Library of Science, 2009-02-10)
      Vertebrate dentitions originated in the posterior pharynx of jawless fishes more than half a billion years ago. As gnathostomes (jawed vertebrates) evolved, teeth developed on oral jaws and helped to establish the dominance ...
    • Anomalies in the Expression Profile of Interspecific Hybrids of Drosophila melanogaster and Drosophila simulans 

      Ranz, José M.; Namgyal, Kalsang; Gibson, Greg; Hartl, Daniel L. (Georgia Institute of TechnologyCold Spring Harbor Laboratory Press, 2004-03)
      When females of Drosophila melanogaster and males of Drosophila simulans are mated, the male progeny are inviable, whereas the female progeny display manifold malformations and are sterile. These abnormalities result from ...
    • Application of DETECTER, an evolutionary genomic tool to analyze genetic variation, to the cystic fibrosis gene family 

      Gaucher, Eric A.; De Kee, Danny W.; Benner, Steven A. (Georgia Institute of TechnologyBioMed Central, 2006-03-07)
      Background: The medical community requires computational tools that distinguish missense genetic differences having phenotypic impact within the vast number of sense mutations that do not. Tools that do this will become ...
    • Are tropical plants better defended? Palatability and defenses of temperate vs. tropical seaweeds 

      Bolser, Robin C.; Hay, Mark E. (Georgia Institute of TechnologyEcological Society of America, 1996-12)
      Investigators working in both terrestrial and marine systems hypothesize that prey defenses are better developed in tropical than in temperate habitats because tropical consumers are more active and diverse. To investigate ...
    • Assessing gene significance from cDNA microarray expression data via mixed models 

      Wolfinger, Russell D.; Gibson, Greg; Wolfinger, Elizabeth D.; Bennett, Lee; Hamadeh, Hisham; Ashari, Cynthia; Paules, Richard S. (Georgia Institute of TechnologyMary Ann Liebert, Inc. Publishers, 2001)
      The determination of a list of differentially expressed genes is a basic objective in many cDNA microarray experiments. We present a statistical approach that allows direct control over the percentage of false positives ...
    • Associational plant defenses and the maintenance of species diversity: turning competitors into accomplices 

      Hay, Mark E. (Georgia Institute of TechnologyUniversity of Chicago Press, 1986-11)
    • Aurora kinase inhibitors synergize with paclitaxel to induce apoptosis in ovarian cancer cells 

      Scharer, Christopher D.; Laycock, Noelani; Osunkoya, Adeboye O.; Logani, Sanjay; McDonald, John F.; Benigno, Benedict B.; Moreno, Carlos S. (Georgia Institute of TechnologyBioMed Central, 2008-12-11)
      Background: A large percentage of patients with recurrent ovarian cancer develop resistance to the taxane class of chemotherapeutics. While mechanisms of resistance are being discovered, novel treatment options and a better ...
    • Autocorrelated exogenous factors and the detection of delayed density dependence 

      Jiang, Lin; Shao, Nan (Georgia Institute of TechnologyEcological Society of America, 2003-08)
      Coupled trophic interactions with specialist predators or resources are thought to be primarily responsible for generating delayed density dependence. Previous theoretical studies suggest that autocorrelation in exogenous ...
    • Bacteria-algae associations in the sea ice and upper water column of the Ross Sea in late austral summer 

      Stewart, Frank J.; Fritsen, Christian H.; Garrison, David L. (Georgia Institute of TechnologyNational Science Foundation, Office of Polar Programs, 2005)
      The ecological role of heterotrophic bacteria in the microbial food web of the Southern Ocean is unresolved. A coupling between phytoplankton and bacterial production is well documented in mid-to low-latitude oceans (e.g., ...
    • Between-habitat differences in herbivore impact on Caribbean coral reefs 

      Hay, Mark E.; Goertemiller, Tim (Georgia Institute of TechnologyU.S. Dept. of Commerce, National Oceanic and Atmospheric Administration, Oceanic and Atmospheric Research, Office of Undersea Research, 1983-12)
      Transplanted sections of the seagrass Thalassia testudinum were used as a bioassay to assess between-habitat differences in herbivory on three Caribbean reefs. Consumption of Thalassia by herbivorous fishes on shallow ...
    • Biochemical Warfare on the Reef: The Role of Glutathione Transferases in Consumer Tolerance of Dietary Prostaglandins 

      Whalen, Kristen E.; Lane, Amy L.; Kubanek, Julia; Hahn, Mark E. (Georgia Institute of TechnologyPublic Library of Science, 2010-01-06)
      Background: Despite the profound variation among marine consumers in tolerance for allelochemically-rich foods, few studies have examined the biochemical adaptations underlying diet choice. Here we examine the role of ...
    • Can quantity replace quality? Food choice, compensatory feeding, and fitness of marine mesograzers 

      Cruz-Rivera, Edwin; Hay, Mark E. (Georgia Institute of TechnologyEcological Society of America, 2000-01)
      Relationships among food choice, compensatory feeding, and the consequences for consumer fitness rarely have been quantified. We created foods of varying nutritional quality and evaluated the consequences of compensatory ...
    • Can small rare prey be chemically defended? the case for marine larvae 

      Lindquist, Niels Lyle; Hay, Mark E. (Georgia Institute of TechnologyEcological Society of America, 1995-06)
      Marine larvae are consumed by a wide variety of generalist fishes and particle—feeding invertebrates, but larvae of any particular species probably constitute a small and variable of the diet for these consumers. Because ...
    • The catabolite activator protein stabilizes its binding site in the E. coli lactose promoter 

      DeGrazia, Henry; Abhiraman, Saraswathy; Wartell, Roger M. (Georgia Institute of TechnologyOxford University Press, 1985-10-25)
      The effect of catabolite activator protein, CAP, on the thermal stability of DNA was examined. Site specific binding was studied with a 62 bp DNA restriction fragment containing the primary CAP site of the E. coli lactose ...