Now showing items 1-20 of 66

    • How many variables? Some comments on the dimensionality of nonlinear systems 

      Voit, Eberhard O. (Georgia Institute of TechnologyWalter de Gruyter, 1992-08)
      While at first glance seemingly obvious, the number of variables in a model is not a priori fixed. For mathematical purposes, it is oftentimes convenient to reduce the number of variables to a minimum, but such reduction ...
    • Nonlinear Wavelet Shrinkage with Bayes Rules and Bayes Factors 

      Vidakovic, Brani (Georgia Institute of TechnologyAmerican Statistical Association, 1998-03)
      Wavelet shrinkage, the method proposed by the seminal work of Donoho and Johnstone is a disarmingly simple and efficient way of denoising data. Shrinking wavelet coefficients was proposed from several optimality criteria. ...
    • Adaptive wavelet estimator for nonparametric density deconvolution 

      Pensky, Marianna; Vidakovic, Brani (Georgia Institute of TechnologyInstitute of Mathematical Statistics, 1999)
      The problem of estimating a density g based on a sample X ₁ X ₂,…,X [subscript n] from p = q ∗ g is considered. Linear and nonlinear wavelet estimators based on Meyer-type wavelets are constructed. The estimators are ...
    • Modeling alternation to synchrony with inhibitory coupling: A neuromorphic VLSI approach 

      Cymbalyuk, Gennady S.; Patel, Girish N.; Calabrese, Ronald L.; DeWeerth, Stephen P.; Cohen, Avis H. (Georgia Institute of TechnologyMIT Press, 2000)
      We developed an analog very large-scale integrated system of two mutually inhibitory silicon neurons that display several different stable oscillations. For example, oscillations can be synchronous with weak inhibitory ...
    • Challenges of Complexity and Integration in Quantitative Systems Biotechnology 

      Voit, Eberhard O. (Georgia Institute of TechnologyNational Science Foundation, 2000-09-13)
      It is widely acknowledged that the enormous amount of data produced by the human and other genome projects requires new mathematical and computational strategies of analysis and integration. Classified very broadly, ...
    • Canonical modeling: a review of concepts with emphasis on environmental health 

      Voit, Eberhard O. (Georgia Institute of TechnologyNational Institute of Environmental Health Sciences, 2000-10)
      The article reviews concepts of canonical modeling in the context of environmental health. Based on biochemical systems theory, the canonical approach was developed over the past thirty years and applied to complex systems ...
    • BAMS Method: Theory and Simulations 

      Vidakovic, Brani; Ruggeri, Fabrizio (Georgia Institute of TechnologyPublished by: Springer on behalf of the Indian Statistical Institute. Article Stable URL: http://www.jstor.org/stable/25053173, 2001-08)
      In this paper we address the problem of model-induced wavelet shrinkage. Assuming the independence model according to which the wavelet coefficients are treated individually, we discuss a level-adaptive Bayesian model in ...
    • A mixed integer horizon formulation for prioritized objective inferential control of a bioprocess system. 

      Long, C. E.; Gatzke, Edward P.; Voit, Eberhard O. (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, Inc., New York, 2003-06)
      This paper presents a model predictive control (MPC) algorithm utilizing a state-space approach that allows for inferential control of unmeasured states using a prioritized control objective formulation. Knowledge of the ...
    • An analog VLSI model of muscular contraction 

      Hudson, Tina A.; Bragg, Julian A.; Hasler, Paul; DeWeerth, Stephen P. (Georgia Institute of TechnologyInstitute of Electrical and Electronics Engineers, 2003-07)
      We have developed analog VLSI circuits to model the behavior demonstrated by biological sarcomeres, the force generating components of muscle tissue. The circuits are based upon the mathematical description of crossbridge ...
    • Extending knowledge of Escherichia coli metabolism by modeling and experiment 

      Voit, Eberhard O.; Riley, Monica (Georgia Institute of TechnologyBioMed Central, 2003-10-28)
      One of the challenges for ‘post-genomic’ biology is the integration of data from many different sources. Two recent studies independently take steps towards this goal for Escherichia coli, using mathematical modeling and ...
    • XML4MAT: Inter-conversion between MatlabTM structured variables and the markup language MbML 

      Almeida, Jonas S.; Wu, Shuyuan; Voit, Eberhard O. (Georgia Institute of TechnologyElsevier, 2003-12)
      The MatlabTM programming environment and related public license environments such as Octave are gaining in popularity for the identification of algorithms and the rapid prototyping of applications in bioinformatics. At ...
    • Dual FRET molecular beacons for mRNA detection in living cells 

      Santangelo, Philip J.; Nix, Brent; Tsourkas, Andrew; Bao, Gang (Georgia Institute of TechnologyOxford University Press, 2004)
      The ability to visualize in real-time the expression level and localization of specific endogenous RNAs in living cells can offer tremendous opportunities for biological and disease studies. Here we demonstrate such a ...
    • Peptide-linked molecular beacons for efficient delivery and rapid mRNA detection in living cells 

      Nitin, Nitin; Santangelo, Philip J.; Kim, Gloria; Nie, Shuming; Bao, Gang (Georgia Institute of TechnologyOxford University Press, 2004)
      Real‐time visualization of specific endogenous mRNA expression in vivo has the potential to revolutionize medical diagnosis, drug discovery, developmental and molecular biology. However, conventional liposome‐ or dendrimer‐based ...
    • Yeast sphingolipid metabolism: clues and connections 

      Sims, Kellie J.; Spassieva, Stefka D.; Voit, Eberhard O.; Obeid, Lina M. (Georgia Institute of TechnologyNational Research Council Canada, 2004-02-26)
      This review of sphingolipid metabolism in the budding yeast Saccharomyces cerevisiae contains information on the enzymes and the genes that encode them, as well as connections to other metabolic pathways. Particular ...
    • Using a hybrid neural system to reveal regulation of neuronal network activity by an intrinsic current 

      Sorensen, Michael; DeWeerth, Stephen P.; Cymbalyuk, Gennady; Calabrese, Ronald L. (Georgia Institute of TechnologySociety for Neuroscience, 2004-06)
      The generation of rhythmic patterns by neuronal networks is a complex phenomenon, relying on the interaction of numerous intrinsic and synaptic currents, as well as modulatory agents. To investigate the functional contribution ...
    • Improved Methods for the Mathematically Controlled Comparison of Biochemical Systems 

      Schwacke, John H.; Voit, Eberhard O. (Georgia Institute of TechnologyBioMed Central Ltd., 2004-06-04)
      The method of mathematically controlled comparison provides a structured approach for the comparison of alternative biochemical pathways with respect to selected functional effectiveness measures. Under this approach, ...
    • Catch bonds govern adhesion through L-selectin at threshold shear 

      Yago, Tadayuki; Wu, Jianhua; Wey, C. Diana; Klopocki, Arkadiusz G.; Zhu, Cheng; McEver, Rodger P. (Georgia Institute of TechnologyRockefeller University Press, 2004-09)
      Flow-enhanced cell adhesion is an unexplained phenomenon that might result from a transport-dependent increase in on-rates or a force-dependent decrease in off-rates of adhesive bonds. L-selectin requires a threshold shear ...
    • Priming nonlinear searches for pathway identification 

      Veflingstad, Siren R.; Almeida, Jonas S.; Voit, Eberhard O. (Georgia Institute of Technology, 2004-09-14)
      Background: Dense time series of metabolite concentrations or of the expression patterns of proteins may be available in the near future as a result of the rapid development of novel, highthroughput experimental techniques. ...
    • Challenges for the identification of metabolic pathways from time series data 

      Voit, Eberhard O.; Marino, Simeone; Lall, Raman (Georgia Institute of TechnologyBioinformation Systems e.V., 2004-12-23)
    • Tracking Retinal Motion with a Scanning Laser Ophthalmoscope 

      Xu, Zhiheng; Schuchard, David Ross; Benkeser, Paul J. (Georgia Institute of TechnologyU.S. Department of Veterans Affairs, 2005)
      MathWorks, Natick, MA) software. The new software technique was experimentally tested on both normal- and low-vision subjects and compared with the results obtained using manual techniques. The findings indicate that the ...