Microstructural Stresses and Strains Associated with Trabecular Bone Microdamage

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1853/14093

Title: Microstructural Stresses and Strains Associated with Trabecular Bone Microdamage
Author: Nagaraja, Srinidhi
Abstract: Bone is a composite material consisting of hydroxyapatite crystals deposited in an oriented manner on a collagen backbone. The arrangement of the mineral and organic phases provides bone tissue with the appropriate strength, stiffness, and fracture resistance properties required to protect vital internal organs and maintain the shape of the body. A remarkable feature of bone is the ability to alter its properties and geometry in response to changes in the mechanical environment. However, in cases of metabolic bone diseases or aging, bone can no longer successfully adapt to its environment, increasing its fragility. To elucidate the mechanisms of bone microdamage, this research project developed a specimen-specific approach that integrated 3D imaging, histological damage labeling, image registration, and image-based finite element analysis to correlate microdamage events with microstructural stresses and strains under compressive loading conditions. By applying this novel method to different ages of bovine and human bone, we have shown that the local mechanical environment at microdamage initiation is altered with age. We have also shown that formation of microdamage is time-dependent and may have implications in age-related microdamage progression with cyclic and/or sustained static loading. The work presented in this dissertation is significant because it improved our understanding of trabecular bone microdamage initiation and unlocked exciting future research directions that may contribute to the development of therapies for fragility diseases such as osteoporosis.
Type: Dissertation
URI: http://hdl.handle.net/1853/14093
Date: 2006-11-17
Publisher: Georgia Institute of Technology
Subject: Microcomputed tomography
Bone mechanics
Microdamage
Trabecular bone
Aging
Finite element analysis
Tomography
Bones Mechanical properties Computer simulation
Bones Microstructure Computer simulation
Department: Mechanical Engineering
Advisor: Committee Chair: Robert E. Guldberg; Committee Member: Christopher S. Lynch; Committee Member: Jiamin Qu; Committee Member: Karl J. Jepsen; Committee Member: Oskar Skrinjar
Degree: Ph.D.

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