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dc.contributor.authorCollins, James P.en_US
dc.date.accessioned2007-03-27T18:22:59Z
dc.date.available2007-03-27T18:22:59Z
dc.date.issued2005-11-28en_US
dc.identifier.urihttp://hdl.handle.net/1853/14095
dc.description.abstractThe problem of forming a glycosidic bond between ribose and the free nucleoside bases to produce beta-nucleosides under plausible prebiotic conditions is commonly referred to in origin of life research as The Nucleoside Problem. The lack of a general solution to this problem currently represents one of the largest stumbling blocks to the RNA world hypothesis and many other theories regarding the origin of life. Over thirty years ago the purine nucleosides were successfully synthesized by drying the fully-formed bases and ribose together in the presence of divalent metal ion salts. However, glycosidic bond formation by the pyrimidine bases has never been achieved under similar reaction conditions. This thesis describes the first plausible prebiotic synthesis of a pyrimidine nucleoside, demonstrated with the pyrimidine base analogue 2-pyrimidinone. Information provided by nucleoside-formation reaction involving 2-pyrimidinone and related pyrimidine bases should provide valuable insights into the possible mechanism by which glycosidic bond formation was accomplished on the prebiotic Earth.en_US
dc.format.extent2501131 bytes
dc.format.mimetypeapplication/pdf
dc.language.isoen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectGlycosidic bonden_US
dc.subject2-pyrimidinoneen_US
dc.subjectNucleosidesen_US
dc.subjectPyrimidineen_US
dc.subjectPrebioticen_US
dc.subjectZebularineen_US
dc.subjectRNA worlden_US
dc.titlePrebiotic Synthesis of Pyrimidine Nucleosidesen_US
dc.typeThesisen_US
dc.description.degreeM.S.en_US
dc.contributor.departmentChemistry and Biochemistryen_US
dc.description.advisorCommittee Chair: Hud, Nicholas; Committee Member: Collard, David; Committee Member: Deutsch, Howard; Committee Member: Orlando, Thomasen_US


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