Show simple item record

dc.contributor.authorOest, Megan Elizabethen_US
dc.date.accessioned2007-08-16T17:55:54Z
dc.date.available2007-08-16T17:55:54Z
dc.date.issued2007-06-28en_US
dc.identifier.urihttp://hdl.handle.net/1853/16264
dc.description.abstractA new model of a critically-sized segmental femoral bone defect in rats was developed to enable in vivo imaging and facilitate post-mortem mechanical testing of samples. The critically-sized nature of the model was assessed and confirmed. The efficacy of sustained co-delivery of osteogenic (BMP-2 and TGF- Ò3) and angiogenic (VEGF) growth factors in promoting functional bone repair was assessed. Effects of scaffold modification in terms of geometry and composition were evaluated. The results indicated that co-delivery of BMP-2 and TGF- Ò3 resulted in a dose-dependent improvement in functional bone repair. Modification of the polylactide scaffold to include an absorbable ceramic component and a cored out geometry enhanced rate of union. Addition of VEGF to the scaffold treatment did not significantly impact revascularization of the defect site or functional repair of the bone defect. These data demonstrate that the complex environment of an acute bone defect requires different treatment strategies than simple ectopic models would suggest. A positive predictive correlation between bone repair parameters measured in vivo and mechanical functionality was established. The novel defect model demonstrated robustness and reproducibility. Implications for further research are discussed.en_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectBone defecten_US
dc.subjectMicro-CTen_US
dc.subjectBMP-2en_US
dc.subjectTGF-beta 3en_US
dc.subjectVEGFen_US
dc.subjectBone repairen_US
dc.subject.lcshBones Wounds and injuriesen_US
dc.subject.lcshBones Growthen_US
dc.subject.lcshBone regenerationen_US
dc.titleDual Osteogenic and Angiogenic Growth Factor Delivery as a Treatment for Segmental Bone Defectsen_US
dc.typeDissertationen_US
dc.description.degreePh.D.en_US
dc.contributor.departmentBiomedical Engineeringen_US
dc.description.advisorCommittee Chair: Robert E. Guldberg; Committee Member: Andres Garcia; Committee Member: David J. Mooney; Committee Member: Ravi Bellamkonda; Committee Member: W. Robert Tayloren_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record