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dc.contributor.authorHill, Elizabeth M.en_US
dc.date.accessioned2007-08-16T17:59:41Z
dc.date.available2007-08-16T17:59:41Z
dc.date.issued2007-07-06en_US
dc.identifier.urihttp://hdl.handle.net/1853/16320
dc.description.abstractSustainable technologies are vital to reducing the environmental impact of chemical enterprises. Solvents are often seen as just a medium in which a reaction takes place; however they can also play a dominant role in the overall toxicity of a typical pharmaceutical/fine chemicals batch chemical operation. Further, careful solvent selection for a reaction may also lead to more facile separation and purification of products, thus reducing the overall cost of a chemical process. This thesis presents an environmentally benign processing technique for sustainable biocatalytic reactions coupled with facile built-in separation. An organic aqueous tunable solvent (OATS) system allows access to a hydrophobic substrate which is transformed with a homogeneous enzymatic catalyst in a single liquid phase. Subsequent CO2 addition produces a biphasic mixture where the hydrophobic product partitions preferentially into the organic rich phase for separation while the hydrophilic enzyme catalyst partitions into the aqueous rich phase, where it is recyclable. Processing parameters in OATS systems are discussed and an overall product recovery of 80% is observed after six reaction cycles. Additionally, greater than 99% enantiomeric excess (ee) is shown for catalyzed hydrolysis of rac-1-phenylethyl acetate with Candida antarctica lipase B (CAL B) both before and after CO2-induced separation.en_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectGas-expanded liquidsen_US
dc.subjectBiphasic separationen_US
dc.subjectBiocatalysisen_US
dc.titleBenign Tunable Solvents for Improved Processing of Pharmaceutically Relevant Products and Catalystsen_US
dc.typeDissertationen_US
dc.description.degreePh.D.en_US
dc.contributor.departmentChemical Engineeringen_US
dc.description.advisorCommittee Co-Chair: Dr. Charles A. Eckert; Committee Co-Chair: Dr. Charles L. Liotta; Committee Member: Dr. Andreas Bommarius; Committee Member: Dr. Carson Meredith; Committee Member: Dr. Hang Luen_US


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