The goal of this seminar series is to to present cutting edge research in Systems Biology.

Recent Submissions

  • Drug Discovery Accelerated by Computational Methods 

    Jorgensen, William L. (Georgia Institute of Technology, 2013-04-30)
    Drug discovery is being pursued through computer-aided design, synthesis, biological assaying, and crystallography. Lead identification features de novo design with the ligand growing program BOMB or docking of commercial ...
  • Mapping Protein Folding on Organismal Fitness One Mutation at a Time 

    Shakhnovich, Eugene (Georgia Institute of Technology, 2013-03-12)
    In this presentation I will describe our efforts at understanding how molecular properties of proteins determine fitness landscape of populations of carrier organisms. Recent multi-scale evolutionary models, which assume ...
  • Histone Variants, Nucleosome Dynamics and Epigenetics 

    Henikoff, Steven (Georgia Institute of Technology, 2013-02-12)
    The Henikoff Lab's recent studies have aimed to understand the elusive relationship between chromatin and epigenetic inheritance. In large part, their focus has been on the universal set of histone variants that replace ...
  • Structural Basis for Iron Piracy by Pathogenic Neisseria 

    Buchanan, Susan (Georgia Institute of Technology, 2012-10-16)
    Neisseria are obligate human pathogens causing bacterial meningitis, septicemia, and gonorrhea. Neisseria require iron for survival and can extract it directly from human transferrin for transport across the outer membrane. ...
  • Development and Evolution of Vertebrate Development and Evolution of Vertebrate 

    Tabin, Clifford (Georgia Institute of Technology, 2012-04-24)
    Dr. Tabin's laboratory studies the genetic basis by which form and structure are regulated during vertebrate development. They combine classical methods of experimental embryology with modern molecular and genetic techniques ...
  • The ESCRT pathway in HIV Budding and Cell Division 

    Sundquist, Wesley (Georgia Institute of Technology, 2012-01-31)
    The Endosomal Sorting Complexes Required for Transport (ESCRT) pathway mediates intraluminal endosomal vesicle formation, budding of HIV-1 and other enveloped viruses, and the final abscission step of cytokinesis in mammals ...
  • New approaches to studying the growth and size regulation of mammalian cells 

    Kirschner, Marc (Georgia Institute of Technology, 2012-01-24)
    The study of cell growth has been limited primarily by the lack of accurate enough means of measuring the growth of cells as they traverse the cell cycle. There are several theoretical models of growth that have been ...
  • New Biology from Natural Metamorphosis of a Conventional Class of Enzymes 

    Schimmel, Paul (Georgia Institute of Technology, 2011-11-15)
    A group of enzymes known as aminoacyl tRNA synthetases interpret genetic information through catalysis of aminoacylation reactions that establish the genetic code. Errors of interpretation are corrected by a universal ...
  • Protein Folding Inside Cells and Other Crowded Environments 

    Gruebele, Martin (Georgia Institute of Technology, 2011-11-08)
    Computer simulations are reaching the point where folding of small proteins in vitro can be successfully achieved ‘ab initio’ by molecular dynamics. Experiments can help further calibrate simulations, and I will discuss ...
  • How do proteins do all of that as seen by hydrogen exchange. Protein folding, GroEL function, lipoprotein structure 

    Englander, S. Walter (Georgia Institute of Technology, 2011-05-10)
    The talk will illustrate the use of hydrogen exchange methods to learn about biophysical properties and functional behaviors of protein molecules. Hydrogen exchange has been measured by older tritium exchange techniques, ...
  • Cheminformatic and assay-performance profiling of small-molecule screening collections 

    Clemons, Paul A . (Georgia Institute of Technology, 2011-05-17)
    Quantitative decisions about properties and behavior of compound sets are important in building screening collections for smallmolecule probes and drugs. Decisions about individual compounds typically dominate such ...
  • Dismantling Complex Problems into their Simple Substrates: From Embryonic Stems Cells to Global Peace 

    Zucker, Howard A. (Georgia Institute of Technology, 2011-03-09)
    In the constantly changing world that we all live in today, problems appear to surface that have many faces depending upon one’s vantage point. At times it may be possible to distill some of the complexities into smaller ...
  • Evolution: from atoms to organisms 

    Shakhnovich, Eugene (Georgia Institute of Technology, 2011-02-15)
    Modern Biology is deeply rooted in Darwinian principles of mutations and selection. Population Genetics aims to address the effects of mutations and selection on populations in a quantitative way within the basic paradigm ...
  • Synthetic Antigen Binders: Novel applications for Structural and Cell Biology 

    Kossiakoff, Anthony A. (Georgia Institute of Technology, 2011-02-08)
    Synthetic Antigen Binders (sABs) are a new class of antibody-based reagents engineered using novel phage display libraries. Using the power of phage display selection, it is possible generate sABs that : 1) target specific ...
  • Chemical genetic investigations of protein and lipid kinase signaling 

    Shokat, Kevan (Georgia Institute of Technology, 2011-01-25)
    Kinases are highly regulated enzymes with diverse mechanisms controlling their catalytic output. Inhibitor discovery efforts for kinases have produced ATP-competitive compounds, allosteric regulators, irreversible binders, ...
  • Active Co-Factors of the Class I RNRs 

    Stubbe, JoAnne (Georgia Institute of Technology, 2010-11-30)
  • Leveraging Protein Structure to Expedite Drug Discovery 

    Brown, Kristin (Georgia Institute of Technology, 2010-11-10)
    Detailed knowledge of a protein family – whether mechanism of action, known active compounds, or three-dimensional structures – can expedite drug discovery. This knowledge is not constrained to the exact protein that is ...
  • Detecting specific nucleic acid sequences under challenging but potentially useful circumstances 

    Cantor, Charles (Georgia Institute of Technology, 2010-11-09)
    In this talk I will describe three circumstances where sensitive detection of nucleic acids leads to practical or useful results. All display synergy between academic research and biotechnology companies. The first, involving ...
  • Elucidating master integrators of tumor-related phenotypes 

    Califano, Andrea (Georgia Institute of Technology, 2010-09-09)
    The identification of genes acting synergistically as master regulators of physiologic and pathologic cellular phenotypes is a key open problem in systems biology, Here we use a molecular interaction based approach to ...
  • Molecular Transport Junctions: Some Mysteries and Some (Partial) Answers 

    Ratner, Mark (Georgia Institute of Technology, 2010-04-20)
    Of the many aspects of electron transfer processes that are significant in the chemical sciences, current/voltage spectroscopy (a focus area of molecular electronics) is one of the newest and most active. The several regimes ...

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