Browsing Distinguished Lecture Series in Systems Biology by Issue Date
Now showing items 1-20 of 34
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From Systems Biology to Systems Analytics: Seeing More by Looking at Less
(Georgia Institute of Technology, 2007-10-09)Systematic analysis of interactions between molecules and biological entities requires the development and application of experimental tools and analytical methods to quantitatively measure and image molecular events, ... -
Relating Cellular to Molecular Specificity – the Recognition Mechanism of Hox Proteins and Cadherins
(Georgia Institute of Technology, 2007-10-23) -
Hybrid Experiments: Linking Real-Time Simulations to In Vitro Electrophysiology Experiments
(Georgia Institute of Technology, 2007-10-30) -
Interactome networks
(Georgia Institute of Technology, 2007-11-27)For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular ... -
Mechanisms of Chromosomal Fragility and Rearrangements Triggered by Human Unstable Repeats
(Georgia Institute of Technology, 2008-01-22)Research of my lab focuses on understanding how chromosomal rearrangements arise and lead to hereditary diseases and cancer. Chromosomes containing repeats that can adopt stable secondary structures are highly prone for ... -
Enabling Mass Spectrometry Technologies for High-Throughput Proteomics and Metabolomics
(Georgia Institute of Technology, 2008-01-29) -
Systems Biology and its Role in Predictive Health and Personalized Medicine
(Georgia Institute of Technology, 2008-02-05) -
Better living through biosensors
(Georgia Institute of Technology, 2008-02-19)The ideal sensor will be sensitive, specific, versatile, small enough to hold in your hand, and selective enough to work even when faced with complex, contaminant-ridden samples. Given the affinity, specificity and ... -
Positive Selection on Non-coding Sequences During Human Evolution: From Genome to Nucleotide
(Georgia Institute of Technology, 2008-03-04) -
New RNA-binding peptidomimetic structures that repress HIV viral replication by specifically inhibiting transcriptional activation
(Georgia Institute of Technology, 2008-03-18)The Interaction between the human immunodeficiency virus (HIV-1) transactivator protein Tat and its response element TAR plays an essential role in viral replication by controlling HIV transcription. Previous attempts to ... -
RNA Enzymes: From Folding to Function in Living Cells
(Georgia Institute of Technology, 2008-03-25)Our research aims to generate fundamental insights into catalysis by RNA enzymes and into the pathways through which RNAs form specific functional structures. RNA catalysis remains an intriguing puzzle that has grown in ... -
Design Rules and Evolutionary Imperatives for a Simple Eukaryote
(Georgia Institute of Technology, 2010-02-23)Construction of a model of the eukaryotic cell with both predictive and explanatory power is a key goal of systems biology. Using a top-down approach, we have identified the cellular components that control growth rate in ... -
The Systems Biology of Parkinson's Disease
(Georgia Institute of Technology, 2010-03-09) -
Understanding Enzymes: Protein Conformation Coupled Catalysis
(Georgia Institute of Technology, 2010-03-23)The role of conformational changes in enzyme catalysis will be discussed. A model will be advanced consisting of conformational ensembles and multiple reaction pathways to explain the incredible catalytic efficiency of ... -
Molecular Transport Junctions: Some Mysteries and Some (Partial) Answers
(Georgia Institute of Technology, 2010-04-20)Of the many aspects of electron transfer processes that are significant in the chemical sciences, current/voltage spectroscopy (a focus area of molecular electronics) is one of the newest and most active. The several regimes ... -
Elucidating master integrators of tumor-related phenotypes
(Georgia Institute of Technology, 2010-09-09)The identification of genes acting synergistically as master regulators of physiologic and pathologic cellular phenotypes is a key open problem in systems biology, Here we use a molecular interaction based approach to ... -
Detecting specific nucleic acid sequences under challenging but potentially useful circumstances
(Georgia Institute of Technology, 2010-11-09)In this talk I will describe three circumstances where sensitive detection of nucleic acids leads to practical or useful results. All display synergy between academic research and biotechnology companies. The first, involving ... -
Leveraging Protein Structure to Expedite Drug Discovery
(Georgia Institute of Technology, 2010-11-10)Detailed knowledge of a protein family – whether mechanism of action, known active compounds, or three-dimensional structures – can expedite drug discovery. This knowledge is not constrained to the exact protein that is ... -
Active Co-Factors of the Class I RNRs
(Georgia Institute of Technology, 2010-11-30) -
Chemical genetic investigations of protein and lipid kinase signaling
(Georgia Institute of Technology, 2011-01-25)Kinases are highly regulated enzymes with diverse mechanisms controlling their catalytic output. Inhibitor discovery efforts for kinases have produced ATP-competitive compounds, allosteric regulators, irreversible binders, ...