Browsing Distinguished Lecture Series in Systems Biology by Title
Now showing items 1-20 of 34
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Active Co-Factors of the Class I RNRs
(Georgia Institute of Technology, 2010-11-30) -
Better living through biosensors
(Georgia Institute of Technology, 2008-02-19)The ideal sensor will be sensitive, specific, versatile, small enough to hold in your hand, and selective enough to work even when faced with complex, contaminant-ridden samples. Given the affinity, specificity and ... -
Chemical genetic investigations of protein and lipid kinase signaling
(Georgia Institute of Technology, 2011-01-25)Kinases are highly regulated enzymes with diverse mechanisms controlling their catalytic output. Inhibitor discovery efforts for kinases have produced ATP-competitive compounds, allosteric regulators, irreversible binders, ... -
Cheminformatic and assay-performance profiling of small-molecule screening collections
(Georgia Institute of Technology, 2011-05-17)Quantitative decisions about properties and behavior of compound sets are important in building screening collections for smallmolecule probes and drugs. Decisions about individual compounds typically dominate such ... -
Design Rules and Evolutionary Imperatives for a Simple Eukaryote
(Georgia Institute of Technology, 2010-02-23)Construction of a model of the eukaryotic cell with both predictive and explanatory power is a key goal of systems biology. Using a top-down approach, we have identified the cellular components that control growth rate in ... -
Detecting specific nucleic acid sequences under challenging but potentially useful circumstances
(Georgia Institute of Technology, 2010-11-09)In this talk I will describe three circumstances where sensitive detection of nucleic acids leads to practical or useful results. All display synergy between academic research and biotechnology companies. The first, involving ... -
Development and Evolution of Vertebrate Development and Evolution of Vertebrate
(Georgia Institute of Technology, 2012-04-24)Dr. Tabin's laboratory studies the genetic basis by which form and structure are regulated during vertebrate development. They combine classical methods of experimental embryology with modern molecular and genetic techniques ... -
Dismantling Complex Problems into their Simple Substrates: From Embryonic Stems Cells to Global Peace
(Georgia Institute of Technology, 2011-03-09)In the constantly changing world that we all live in today, problems appear to surface that have many faces depending upon one’s vantage point. At times it may be possible to distill some of the complexities into smaller ... -
Drug Discovery Accelerated by Computational Methods
(Georgia Institute of Technology, 2013-04-30)Drug discovery is being pursued through computer-aided design, synthesis, biological assaying, and crystallography. Lead identification features de novo design with the ligand growing program BOMB or docking of commercial ... -
Elucidating master integrators of tumor-related phenotypes
(Georgia Institute of Technology, 2010-09-09)The identification of genes acting synergistically as master regulators of physiologic and pathologic cellular phenotypes is a key open problem in systems biology, Here we use a molecular interaction based approach to ... -
Enabling Mass Spectrometry Technologies for High-Throughput Proteomics and Metabolomics
(Georgia Institute of Technology, 2008-01-29) -
The ESCRT pathway in HIV Budding and Cell Division
(Georgia Institute of Technology, 2012-01-31)The Endosomal Sorting Complexes Required for Transport (ESCRT) pathway mediates intraluminal endosomal vesicle formation, budding of HIV-1 and other enveloped viruses, and the final abscission step of cytokinesis in mammals ... -
Evolution: from atoms to organisms
(Georgia Institute of Technology, 2011-02-15)Modern Biology is deeply rooted in Darwinian principles of mutations and selection. Population Genetics aims to address the effects of mutations and selection on populations in a quantitative way within the basic paradigm ... -
From Systems Biology to Systems Analytics: Seeing More by Looking at Less
(Georgia Institute of Technology, 2007-10-09)Systematic analysis of interactions between molecules and biological entities requires the development and application of experimental tools and analytical methods to quantitatively measure and image molecular events, ... -
Histone Variants, Nucleosome Dynamics and Epigenetics
(Georgia Institute of Technology, 2013-02-12)The Henikoff Lab's recent studies have aimed to understand the elusive relationship between chromatin and epigenetic inheritance. In large part, their focus has been on the universal set of histone variants that replace ... -
How do proteins do all of that as seen by hydrogen exchange. Protein folding, GroEL function, lipoprotein structure
(Georgia Institute of Technology, 2011-05-10)The talk will illustrate the use of hydrogen exchange methods to learn about biophysical properties and functional behaviors of protein molecules. Hydrogen exchange has been measured by older tritium exchange techniques, ... -
Hybrid Experiments: Linking Real-Time Simulations to In Vitro Electrophysiology Experiments
(Georgia Institute of Technology, 2007-10-30) -
Interactome networks
(Georgia Institute of Technology, 2007-11-27)For over half a century it has been conjectured that macromolecules form complex networks of functionally interacting components, and that the molecular mechanisms underlying most biological processes correspond to particular ... -
Leveraging Protein Structure to Expedite Drug Discovery
(Georgia Institute of Technology, 2010-11-10)Detailed knowledge of a protein family – whether mechanism of action, known active compounds, or three-dimensional structures – can expedite drug discovery. This knowledge is not constrained to the exact protein that is ... -
Mapping Protein Folding on Organismal Fitness One Mutation at a Time
(Georgia Institute of Technology, 2013-03-12)In this presentation I will describe our efforts at understanding how molecular properties of proteins determine fitness landscape of populations of carrier organisms. Recent multi-scale evolutionary models, which assume ...