Mechanisms of Chromosomal Fragility and Rearrangements Triggered by Human Unstable Repeats

Show simple item record Lobachev, Kirill 2008-01-30T14:29:50Z 2008-01-30T14:29:50Z 2008-01-22
dc.description Kirill Lobachev, Assistant Professor, Department of Biology, Georgia Tech, presented a lecture at 11:00 AM, Tuesday, January 22, 2008, Klaus Advanced Computing Building, Room 1116W en_US
dc.description Runtime: 47:50 minutes
dc.description.abstract Research of my lab focuses on understanding how chromosomal rearrangements arise and lead to hereditary diseases and cancer. Chromosomes containing repeats that can adopt stable secondary structures are highly prone for double-strand breaks and various types of rearrangements. Molecular mechanisms for this type of genetic instability in eukaryotes are poorly understood. Using yeast, S. cerevisiae, we are investigating the chromosomal fragility mediated by two sequence motifs: cruciform-forming inverted repeats and H-DNA-forming GAA/TTC triplet repeats. Both types of repeats strongly induce breakage which results from the replication arrest by the secondary structures. However, genetic requirements for fragility, mode of breakage and consequences for the genome integrity are different for these two types of repeats. We propose that the nature of the secondary structure predisposes chromosomes for the specific pattern of gross chromosomal rearrangements. These rearrangements are strikingly similar to carcinogenic aberration suggesting that repeat-mediated instability might be a general phenomenon that operates not only in yeast but also in humans. I will present recent data from my lab on proteins that are involved into the fragility. en_US
dc.format.extent 47:50 minutes
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Chromosome fragility en_US
dc.subject Chromosomal rearrangements en_US
dc.subject Hereditary diseases en_US
dc.subject Cancer en_US
dc.subject Double-strand breaks
dc.title Mechanisms of Chromosomal Fragility and Rearrangements Triggered by Human Unstable Repeats en_US
dc.type Lecture en_US
dc.type Video
dc.contributor.corporatename Georgia Institute of Technology. Institute for Bioengineering and Bioscience
dc.contributor.corporatename Georgia Institute of Technology. School of Biology

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