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dc.contributor.authorLobachev, Kirill
dc.date.accessioned2008-01-30T14:29:50Z
dc.date.available2008-01-30T14:29:50Z
dc.date.issued2008-01-22
dc.identifier.urihttp://hdl.handle.net/1853/19406
dc.descriptionKirill Lobachev, Assistant Professor, Department of Biology, Georgia Tech, presented a lecture at 11:00 AM, Tuesday, January 22, 2008, Klaus Advanced Computing Building, Room 1116Wen_US
dc.descriptionRuntime: 47:50 minutes
dc.description.abstractResearch of my lab focuses on understanding how chromosomal rearrangements arise and lead to hereditary diseases and cancer. Chromosomes containing repeats that can adopt stable secondary structures are highly prone for double-strand breaks and various types of rearrangements. Molecular mechanisms for this type of genetic instability in eukaryotes are poorly understood. Using yeast, S. cerevisiae, we are investigating the chromosomal fragility mediated by two sequence motifs: cruciform-forming inverted repeats and H-DNA-forming GAA/TTC triplet repeats. Both types of repeats strongly induce breakage which results from the replication arrest by the secondary structures. However, genetic requirements for fragility, mode of breakage and consequences for the genome integrity are different for these two types of repeats. We propose that the nature of the secondary structure predisposes chromosomes for the specific pattern of gross chromosomal rearrangements. These rearrangements are strikingly similar to carcinogenic aberration suggesting that repeat-mediated instability might be a general phenomenon that operates not only in yeast but also in humans. I will present recent data from my lab on proteins that are involved into the fragility.en_US
dc.format.extent47:50 minutes
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectChromosome fragilityen_US
dc.subjectChromosomal rearrangementsen_US
dc.subjectHereditary diseasesen_US
dc.subjectCanceren_US
dc.subjectDouble-strand breaks
dc.titleMechanisms of Chromosomal Fragility and Rearrangements Triggered by Human Unstable Repeatsen_US
dc.typeLectureen_US
dc.typeVideo
dc.contributor.corporatenameGeorgia Institute of Technology. Institute for Bioengineering and Bioscience
dc.contributor.corporatenameGeorgia Institute of Technology. School of Biology


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