High-Throughput Screening of Advanced Polymeric Materials
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In this talk Professor Meredith reviewed recent advances in the high-throughput screening of polymers for advanced materials. Two applications were reviewed: proton exchange membranes (PEM) and biomaterials for cell adhesion and growth. After decades of research the essential requirements of successful PEMs are understood reasonably well. But still, even with design information available, there are millions of potential candidate materials: more than can be reasonably evaluated experimentally. A new approach for searching this space of materials more efficiently would lead to PEMs with significantly better performance-to-price characteristics. This talk reviewed a combinatorial screening system that integrates synthesis of sample libraries based on composition gradients, high-throughput screening of conductivity, mechanical properties, and transport properties. A significant challenge encountered in high-throughput research and development of organic and polymeric materials is the reproducible preparation of combinatorial libraries with programmed variations in composition. A number of examples of discrete and gradient library preparation techniques have been presented in the literature, which were reviewed in this talk. The application of these novel techniques to polymeric biomaterials was also covered. The HTS protocol has been utilized to discover microphase-separated patterns that enhance cell attachment and proliferation for osteoblasts (bone). Informatics processing and models that enable optimization of large materials data sets was also discussed in reference to biomaterials screening.
- Nano@Tech Lecture Series