Show simple item record

dc.contributor.authorBark, David Lawrence, Jr.en_US
dc.date.accessioned2008-06-10T20:36:28Z
dc.date.available2008-06-10T20:36:28Z
dc.date.issued2007-04-19en_US
dc.identifier.urihttp://hdl.handle.net/1853/22550
dc.description.abstractA computational model of thrombus initiation and aggrandizement was proposed. The model separated the thrombotic process into three mechanisms, including shear enhanced diffusivity, platelet margination, and platelet adhesion. The model indicates that transport mechanisms may be the rate limiting condition of thrombus formation at physiological shear rates and that at higher shear rates; platelet binding becomes the rate limiting condition. Additionally a wall shear rate of 20000 s-1 and above should be considered as a new criterion for prophylactic treatment of an atherosclerotic lesion.en_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectDiffusionen_US
dc.subjectAdhesionen_US
dc.subjectArteriosclerosisen_US
dc.subjectAtherosclerosisen_US
dc.subjectPlateleten_US
dc.subjectThrombosisen_US
dc.subjectThrombusen_US
dc.subjectBlooden_US
dc.subject.lcshThrombosis
dc.subject.lcshComputational fluid dynamics
dc.subject.lcshBlood platelets
dc.subject.lcshTransport theory
dc.subject.lcshCell adhesion
dc.subject.lcshShear flow
dc.titleMechanistic numerical study of trhombus growthen_US
dc.typeThesisen_US
dc.description.degreeM.S.en_US
dc.contributor.departmentMechanical Engineeringen_US
dc.description.advisorCommittee Chair: David N. Ku; Committee Member: Cyrus Aidun; Committee Member: Don P. Giddensen_US


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record