Scanning Mass Spectrometry (SMS) Probe

Show simple item record Kottke, Peter 2008-06-25T20:02:45Z 2008-06-25T20:02:45Z 2008-04-08
dc.description Peter Kottke, a research engineer in the School of Mechanical Engineering presented a lecture at the Nano@Tech Meeting on April 8, 2008 at 12 noon in room 102 of the MiRC building en_US
dc.description Runtime: 42:17 minutes
dc.description.abstract Peter Kottke described the SMS probe, a tool currently under development for mass spectrometric imaging of live biological samples in vitro. In order to obtain spatially resolved images of chemical species distributions in vitro, an ion source is needed that samples from a small volume of liquid. The SMS probe is based on a novel approach to electrospray ionization (reverse-Taylor-cone electrospray), which requires a reversal of orientation of conventional electrospray ionization (ESI) sampling. Electrospray ionization mass spectrometry (ESI-MS) has the advantage of providing a means for transferring large biological molecules directly from solution into the gas phase under atmospheric pressure. The unique advantages of the reverse-Taylor-cone ionization concept are the minimum and highly localized (in space) sample volume (i.e., high resolution) that is being probed and, most importantly, its unique suitability for use in scanning probe chemical imaging applications, including imaging biological samples under physiological conditions (i.e., in aqueous solution). en_US
dc.format.extent 42:17 minutes
dc.language.iso en_US en_US
dc.publisher Georgia Institute of Technology en_US
dc.subject Nanotechnology en_US
dc.subject Mass spectrometry en_US
dc.subject SMS probe en_US
dc.subject Reverse-Taylor-cone ionization en_US
dc.subject Electrospray ionization
dc.subject Porous aluminum oxide
dc.title Scanning Mass Spectrometry (SMS) Probe en_US
dc.type Lecture en_US
dc.type Video
dc.contributor.corporatename Georgia Institute of Technology. School of Mechanical Engineering

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