Now showing items 1-6 of 6
DBD-Hunter: a knowledge-based method for the prediction of DNA protein interactions
(Georgia Institute of Technology, 2008-05-31)
The structures of DNA–protein complexes have illuminated the diversity of DNA–protein binding mechanisms shown by different protein families. This lack of generality could pose a great challenge for predicting DNA–protein ...
From Nonspecific DNA–Protein Encounter Complexes to the Prediction of DNA–Protein Interactions
(Georgia Institute of Technology, 2009-04-03)
DNA–protein interactions are involved in many essential biological activities. Because there is no simple mapping code between DNA base pairs and protein amino acids, the prediction of DNA–protein interactions is a ...
A Threading-Based Method for the Prediction of DNABinding Proteins with Application to the Human GenomeProteins with Application to the Human Genome
(Georgia Institute of Technology, 2009-11-13)
Diverse mechanisms for DNA-protein recognition have been elucidated in numerous atomic complex structures from various protein families. These structural data provide an invaluable knowledge base not only for understanding ...
Simulated refolding of stretched titin immunoglobulin domains
(Georgia Institute of Technology, 2001-10)
Steered molecular dynamics (SMD) is used to investigate forced unfolding and spontaneous refolding of immunoglobulin I27, a domain of the muscle protein titin. Previous SMD simulations revealed the events leading to ...
Steered molecular dynamics studies of titin I1 domain unfolding
(Georgia Institute of Technology, 2002-12)
The cardiac muscle protein titin, responsible for developing passive elasticity and extensibility of muscle, possesses about 40 immunoglobulin-like (Ig) domains in its I-band region. Atomic force microscopy (AFM) and steered ...
Onset of anthrax toxin pore formation
(Georgia Institute of Technology, 2006-05)
Protective antigen (PA) is the anthrax toxin protein recognized by capillary morphogenesis gene 2 (CMG2), a transmembrane cellular receptor. Upon activation, seven ligand-receptor units self-assemble into a heptameric ...