Dissolving Microneedles for Transdermal Drug Delivery

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1853/26724

Title: Dissolving Microneedles for Transdermal Drug Delivery
Author: Lee, Jeong Woo
Abstract: Microfabrication technology has been adapted to produce micron- scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines. This study presents a novel design that encapsulates sensitive biomolecules within microneedles that dissolve within the skin for bolus or sustained delivery and leave behind no biohazardous sharp medical waste. A novel fabrication process was developed based on casting a viscous aqueous solution during centrifugation to fill a micro-fabricated mold with biocompatible carboxymethylcellulose or amylopectin formulations. This process encapsulated sulforhodamine B, bovine serum albumin, and lysozyme as model drugs; lysozyme was shown to retain full enzymatic activity after encapsulation and to remain 96% active after storage for two months at room temperature. Microneedles were also shown to be strong enough to insert into human cadaver skin and then to dissolve within minutes. Bolus delivery was achieved by encapsulating model drug just within microneedle shafts. For the first time, sustained delivery over hours to days was achieved by encapsulating drug within the microneedle backing, which served as a controlled release drug reservoir that delivered drug by a combination of swelling the backing with interstitial fluid drawn out of the skin and drug diffusion into the skin via channels formed by dissolved microneedles. We conclude that dissolving microneedles can be designed to encapsulate sensitive biomolecules, insert into skin, and enable bolus or sustained release drug delivery.
Description: 2008 Ziegler Award Winner, presented as a keynote address at the 2008 School of Chemical and Biomolecular Engineering Fourth Year Colloquium, Wednesday October 22, 2008. Runtime: 27:57 minutes
Type: Presentation
URI: http://hdl.handle.net/1853/26724
Date: 2008-10-22
Contributor: Georgia Institute of Technology. School of Chemical and Biomolecular Engineering
Emory University. Dept. of Biomedical Engineering
Georgia Institute of Technology. Dept. of Biomedical Engineering
Relation: School of Chemical and Biomolecular Engineering Seminar Series
Publisher: Georgia Institute of Technology
Subject: Microfabrication
Minimally invasive
Protein delivery
Transdermal drug delivery

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