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dc.contributor.authorLee, Jeong Woo
dc.date.accessioned2009-01-27T13:12:23Z
dc.date.available2009-01-27T13:12:23Z
dc.date.issued2008-10-22
dc.identifier.urihttp://hdl.handle.net/1853/26724
dc.description2008 Ziegler Award Winner, presented as a keynote address at the 2008 School of Chemical and Biomolecular Engineering Fourth Year Colloquium, Wednesday October 22, 2008.
dc.descriptionRuntime: 27:57 minutes
dc.description.abstractMicrofabrication technology has been adapted to produce micron- scale needles as a safer and painless alternative to hypodermic needle injection, especially for protein biotherapeutics and vaccines. This study presents a novel design that encapsulates sensitive biomolecules within microneedles that dissolve within the skin for bolus or sustained delivery and leave behind no biohazardous sharp medical waste. A novel fabrication process was developed based on casting a viscous aqueous solution during centrifugation to fill a micro-fabricated mold with biocompatible carboxymethylcellulose or amylopectin formulations. This process encapsulated sulforhodamine B, bovine serum albumin, and lysozyme as model drugs; lysozyme was shown to retain full enzymatic activity after encapsulation and to remain 96% active after storage for two months at room temperature. Microneedles were also shown to be strong enough to insert into human cadaver skin and then to dissolve within minutes. Bolus delivery was achieved by encapsulating model drug just within microneedle shafts. For the first time, sustained delivery over hours to days was achieved by encapsulating drug within the microneedle backing, which served as a controlled release drug reservoir that delivered drug by a combination of swelling the backing with interstitial fluid drawn out of the skin and drug diffusion into the skin via channels formed by dissolved microneedles. We conclude that dissolving microneedles can be designed to encapsulate sensitive biomolecules, insert into skin, and enable bolus or sustained release drug delivery.en
dc.format.extent27:57 minutes
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen
dc.relation.ispartofseriesSchool of Chemical and Biomolecular Engineering Seminar Seriesen_US
dc.subjectMicrofabricationen
dc.subjectMicroneedlesen
dc.subjectMinimally invasiveen
dc.subjectPolysaccharideen
dc.subjectProtein deliveryen
dc.subjectTransdermal drug deliveryen
dc.titleDissolving Microneedles for Transdermal Drug Deliveryen
dc.typePresentationen
dc.typeVideo
dc.contributor.corporatenameGeorgia Institute of Technology. School of Chemical and Biomolecular Engineering
dc.contributor.corporatenameEmory University. Dept. of Biomedical Engineering
dc.contributor.corporatenameGeorgia Institute of Technology. Dept. of Biomedical Engineering


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