Steroidogenesis-inducing protein: An enigmatic protein with multiple biological functions

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dc.contributor.author Khan, Shafiq A.
dc.date.accessioned 2009-02-10T19:50:32Z
dc.date.available 2009-02-10T19:50:32Z
dc.date.issued 2008-10-09
dc.identifier.uri http://hdl.handle.net/1853/26934
dc.description Presented on October 9, 2008 from 11:00 AM – 12:00 PM in room L1205, Ford Environmental Science & Technology Building (ES&T) on the Georgia Tech campus. en
dc.description Runtime: 45:57 minutes
dc.description.abstract SIP was isolated and characterized from human ovarian follicular fluid in our laboratory on the basis of its profound effects on steroid production in testicular, ovarian and adrenal cells. Later studies showed that SIP is also a potent mitogen and stimulated DNA synthesis in testicular Leydig cells, ovarian granulosa cells and in cell lines derived from ovarian epithelial carcinomas. Partial amino acid sequence analysis of this protein revealed that SIP is a novel protein which shows similarities with immunoglobulins and with a recently characterized DING family of proteins. Antibodies raised against specific SIP peptide blocked the activity of SIP on DNA synthesis and on steroid production in testicular cells. Using these antibodies we also determined the expression of SIP in different tissues and cell lines including prostate cancer cells. A SIP protein was detected in the rat testes, ovarian granulosa cells, ovarian epithelial cancer cell lines and in several prostate cancer cell lines. Furthermore, treatment with purified SIP resulted in induction of proliferation of prostate cancer cells similar to that seen in ovarian cancer cells and in other cell types. Based on these studies we hypothesize that SIP is produced by prostate cancer cells in the advanced stages of disease and serves as an autocrine regulator of cell proliferation in these cells. Furthermore, we hypothesize that SIP may exert its steroidogenic effects on these cells resulting in synthesis of steroids which may serve as ligands for AR and hence may lead to insensitivity to exogenous androgens
dc.format.extent 45:57 minutes
dc.language.iso en_US en
dc.publisher Georgia Institute of Technology en
dc.subject Cancer biology en
dc.subject Steroidogenesis en
dc.subject Reproductive system en
dc.title Steroidogenesis-inducing protein: An enigmatic protein with multiple biological functions en
dc.type Lecture en
dc.type Video
dc.contributor.corporatename Clark Atlanta University. Center for Cancer Research and Therapeutic Development
dc.contributor.corporatename Georgia Institute of Technology. School of Biology


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