Computer simulation of the folding of coiled coils

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1853/27015

Title: Computer simulation of the folding of coiled coils
Author: Rey, Antonio ; Skolnick, Jeffrey
Abstract: A simple model capable of providing possible folding pathways of two stranded, coiled coil peptides is described and simulated using an off-lattice dynamic Monte Carlo algorithm. Short sequences of very regular repetitive blocks of amino acids are studied. The regularity of the sequence is enhanced by a simplified interaction scale between pairs of residues. Following the transition from two isolated chains in a random conformation to the folded dimeric structure, the main features capable of obtaining a parallel, in-register, unique conformation, are examined. These include the geometrical representation of the model, the cooperative development of secondary and tertiary structures, and the role of tertiary interactions stabilizing the coiled coil geometry. The influence of introducing disulfide bridges in certain locations of the sequence is also discussed.
Description: ©1994 American Institute of Physics The electronic version of this article is the complete one and can be found online at: http://link.aip.org/link/?JCPSA6/100/2267/1 DOI:10.1063/1.466525
Type: Article
URI: http://hdl.handle.net/1853/27015
ISSN: 0021-9606
Citation: Journal of Chemical Physics, 1994:100: 2267-2276
Date: 1994-02-01
Contributor: Universidad Complutense de Madrid. Departamento de Química Física I
Scripps Research Institute. Dept. of Molecular Biology
Publisher: Georgia Institute of Technology
American Institute of Physics
Subject: Computerized simulation
Peptides
Folding model
Monte Carlo method
Simulation
Algorithms
Amino acids
Chains
Randomness
Conformational changes
Dimers
Proteins

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