Mechanisms of Embryonic Stem Cell Self-Renewal
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Embryonic stem (ES) cells have the capacity for unlimited proliferation and differentiation into a wide range of cell types. Our long-term goals are to define the molecular mechanisms underpinning self-renewal and pluripotency of murine ES cells with the expectation that this information will; (i) define fundamental mechanisms of early embryonic development and, (ii) generate enabling technology that will give utility to ES cells in the area of regenerative medicine. This talk will focus on the molecular mechanisms underpinning self-renewal mechanisms of ES cells and will consider the similarities between stem cells and tumor cells.