Browsing Petit Institute Breakfast Club Seminar Series by Issue Date
Now showing items 1-20 of 51
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Evolutionary Role of DNA Methylation in Animal Genomes
(Georgia Institute of Technology, 2008-10-21)DNA methylation is a primary epigenetic mechanism involved in several regulatory and developmental processes. In this talk, I will focus on the molecular evolutionary role of DNA methylation. An important property of DNA ... -
Engineering Stem Cell Technologies
(Georgia Institute of Technology, 2009-04-21)The McDevitt laboratory is focused on the engineering of innovative technologies to translate the regenerative potential of stem cells into effective cellular and molecular therapies for the treatment of degenerative ... -
Towards an Evolutionary Synthetic Biology
(Georgia Institute of Technology, 2009-11-10)Evolution is the unifying theory behind biology, and has entered the mainstream of computational and molecular biology as a result of genomics. Nevertheless, evolutionary ideas today only barely influence the practice ... -
Human Repetitive DNA Sequences as a Source of Chromosomal Fragility and Genome Rearrangements in Yeast: Implications for Human Polymorphisms and Diseases
(Georgia Institute of Technology, 2010-02-16)Eukaryotic chromosomes must be accurately maintained, duplicated and segregated during mitotic and meiotic divisions to guarantee inheritance of the correct genetic information by the daughter cells. However, occasionally ... -
Biomechanics and Remodeling in Native and Engineered Arteries
(Georgia Institute of Technology, 2010-04-20)Despite advances over the past 25 years, a pressing clinical need remains to develop small diameter tissue engineered blood vessels (TEBV) with low thrombogenicity and immune responses, suitable mechanical properties, and ... -
Designing Cell Instructive Extracellular Matrices
(Georgia Institute of Technology, 2010-09-14) -
Novel Strategies for Treating Cardiac Dysfunction
(Georgia Institute of Technology, 2010-10-12) -
The Center for Integrative Genomics and Predictive Health in Atlanta
(Georgia Institute of Technology, 2010-11-09)I will give a two-part talk that starts with a discussion of my groups research on genomic profiling in human populations, and leads to a presentation of my vision of the relationship of the Center for Integrative Genomics ... -
Reading and Writing the Neural Code
(Georgia Institute of Technology, 2011-01-18)The external world is represented in the brain as spatiotemporal patterns of electrical activity. Sensory signals, such as light, sound, and touch, are transduced at the periphery and subsequently transformed by various ... -
Small RNA Regulation of the Quorum Sensing Response in the Bacterial Pathogen Vibrio Cholerae
(Georgia Institute of Technology, 2011-06-14)Vibrio cholerae, the waterborne bacterium responsible for the deadly disease cholera, is both a transient human pathogen and a ubiquitous inhabitant of marine environments. The pathogenesis and ecology of this deadly ... -
Social Biology of Insects
(Georgia Institute of Technology, 2011-07-12)Biological complexity has increased through a series of major evolutionary transitions. One of the most recent transitions occurred when individually reproducing organisms came together to form integrated social groups. ... -
Medical Decision Making: A Machine Learning Framework for Classification in Medicine and Biology
(Georgia Institute of Technology, 2011-08-09)Systems modeling and quantitative analysis of large amounts of complex clinical and biological data may help to identify discriminatory patterns that can uncover health risks, detect early disease formation, monitor ... -
“What’s Eating You?” Quantifying Proteolytic Activity in Health and Disease with Novel Assays and Computational Models
(Georgia Institute of Technology, 2011-09-13)Cathepsins are enzymes with the most powerful human collagenase and elastase activity that are upregulated at sites of normal tissue remodeling and during tissue-destructive disease progression. We study them in the context ... -
The Two Unknowns of Nucleosomes: How They Are Formed and How They Are Removed
(Georgia Institute of Technology, 2012-03-13)In eukaryotes, the genomic DNA is highly packaged inside the nucleus of a cell by forming beads-on-a string-like structure called nucleosomes. The propensity of a ~150-bp duplex DNA to form a nucleosome, termed the ... -
Ant Rafts and Other Water Repellent Systems
(Georgia Institute of Technology, 2012-04-10)We present a series of experiments demonstrating the water-repellent adaptations of a range of animals, from insects to mammals. These adaptations are necessary for survival in rain and other wet environments. During ... -
Warding Off Disease on Coral Reefs: Antimicrobial Chemical Cues and their Future in Drug Discovery
(Georgia Institute of Technology, 2012-05-08)Unlike many animals, seaweeds do not possess adaptive immune systems to ward off disease. In many cases, they produce small molecules – natural antibiotics – that prevent colonization or infection by pathogens. We have ... -
Uncovering Metabolic Regulation and Dynamics
(Georgia Institute of Technology, 2012-07-10)Understanding and controlling cellular metabolism (the process by which nutrients taken into a cell are turned into energy and the building blocks for more cells) is crucial to numerous applications, from enabling more ... -
Mesenchymal Stem Cell Angiogenic Capacity in Amputated Limbs
(Georgia Institute of Technology, 2012-12-11)Patients with critical limb ischemia have inadequate perfusion for resting nutritional needs leading to rest pain, ulceration, and eventually major amputation or death. Approximately half of critical limb ischemia patients ... -
Exploring Lymphatic Function: An Engineered Toolbox to Shed Light on Nature’s Invisible Vessels
(Georgia Institute of Technology, 2013-01-08)Proper lymphatic function is essential to a variety of important physiologic processes including immune cell trafficking, lipid absorption, and the regulation of fluid balance. However, the experimental difficulties ... -
Ocular Biomechanics: Lots of Good Problems Looking for Solutions
(Georgia Institute of Technology, 2013-04-09)Eyes matter – vision loss is consistently rated as one of the most feared disabilities and blindness imposes huge social and economic costs. Good human vision requires, among other processes, biomechanical homeostasis ...
