Engineering Stem Cell Technologies

Abstract

The McDevitt laboratory is focused on the engineering of innovative technologies to translate the regenerative potential of stem cells into effective cellular and molecular therapies for the treatment of degenerative diseases and traumatic injuries. By developing controlled systems approaches to engineer the microenvironment of stem cells, we aspire to improve the efficiency and yield of directed stem cell differentiation strategies. We also seek to develop novel regenerative molecular therapies based on the morphogens produced by stem cells. Efficient scalable bioprocesses will require the development of enabling tools and technologies to facilitate the production of stem cell technologies. The combination of directed stem cell differentiation and derivation of stem cell biotherapeutics will yield fresh insights into stem cell biology and facilitate new regenerative therapies.