Department of Biomedical Engineering Undergraduate Research Option Theses
The Research Option offers students majoring in biomedical engineering the opportunity for a substantial, in-depth research experience. Students are strongly encouraged at the end of their experience to work with their faculty mentor to develop a journal publication or conference presentation on the research in addition to the actual thesis.
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Recent Submissions
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Biofilm Matrix Properties in Pseudomonas aeruginosa under Bacteriophage Treatment
Biofilms are a specialized structural formation that some bacterial species form when growing in certain environments. One such environment is the human lung, where the bacteria Pseudomonas aeruginosa forms biofilms that ... -
Dissociable Effect of Stimulus Fluency on Accuracy and Confidence in Perceptual Decision Making
Perceptual decision making relies on collecting evidence from stimuli to make an accurate judgement. The decision is accompanied by a sense of confidence based on the same evidence. Although the accuracy and confidence of ... -
An investigation of the mechanism behind Adjuplex and its effect in adjuvant combinations
This research thesis contributes to the field of biomedical engineering, specifically to the following topics: immunotherapy, drug delivery, and adjuvant-vaccine work. By utilizing RAW-Blue cells to observe IFN-β production, ... -
Ability of Janus Particle as Single Cell Sensor to Immobilize Plasma Cells and Collect Antibody
The method to identify and isolate the proteins is one of the keys to the immunoassay production. However, currently there is no effective way to isolate the protein not only because of limited number of technologies for ... -
Design and Validation of a Handheld Probe to Measure Knee Joint Sounds
The goal of this research is to design and validate a system used to record joint sounds measurements that can be collected at home by patients. Wearable and handheld technology allows patients to monitor conditions at ... -
AxoNet: A Deep Learning-based Tool to Count Retinal Ganglion Cell Axons
In this work, we develop a robust, extensible tool to automatically and accurately count retinal ganglion cell axons in optic nerve (ON) tissue images from various animal models of glaucoma. We adapted deep learning to ... -
A Comparison Study on the Effects of Polycaprolactone Degradation Using Different 3D Bio-Printing Technologies
Polycaprolactone (PCL) is a respected polymer for bio-implantation in the field of tissue engineering for scaffolding due to the its compatible and slow bio-degradation properties. While studies have been conducted on the ... -
Gold Nanoparticles Treatment in MCF-7 Spheroid Co-Cultures With Dendritic Cells
In the last decade biomaterials have increasingly been studied as the next generation of immunotherapeutic treatments for their tendency to induce host response against themselves when implanted. Addressing this significant ... -
Force-Signaling Coupling at Single Focal Adhesions
Cell adhesion to extracellular matrices (ECM) is regulated by integrin receptors. After binding to ECM proteins, integrin clustering occurs to form focal adhesion (FA) complexes. These complexes contain proteins that link ... -
The Phenotypic Response of Dendritic Cells to Gold Nanoparticles Treatments
Immunotherapy research has been increasingly investigating the potential of gold nanoparticles (AuNPs). AuNPs pose new benefits in the medical field ranging from diagnostics to diseases treatment. AuNPs’ ability to infiltrate ... -
Investigation of the Cytokine and Chemokine Response of Dendritic Cells Following Gold Nanoparticle Treatments and Variations in Hydrogels
Immunotherapies have significant potential for implementation towards personalized medicine through avenues such as vaccine, gene, and cancer applications. Dendritic cells are a major contributor in the immune system, ... -
Pulsatile Flow System for Surgical Robotics
Surgical robotics is an evolving field where robotic medical devices are utilized to perform surgery either on or within the body. In order to mitigate errors that may occur during surgery due to the medical devices being ... -
Efficacy of an International Student Orientation Course
Culture shock is a prominent phenomenon for international students when beginning college. The term ‘culture shock’ is defined as a negative emotional reaction caused by the overwhelming and confusing flood of unfamiliar ... -
Characterizing Heme Signaling and Bioavailability in Neurodegeneration
Alzheimer’s disease is a neurodegenerative condition that results in cognitive decline, impacting over 40 million people worldwide. Alzheimer’s is characterized by amyloid beta plaques, tau tangles and neuroinflammation. ... -
An Ex Vivo Model of Oxidative Stress Induced Trabecular Meshwork Dysfunction for Glaucomca Research
Affecting more than 70 million people worldwide, glaucoma is one of the leading causes of vision loss and blindness. Although the exact origins of glaucoma are still unknown, elevated intraocular pressure is a well-established ... -
Surface Bioengineering on a Triboelectric Nanogenerator (TENG) Device
Using biocompatible materials to develop inexpensive, self-powered devices is significant for novel clinical applications. Here we report the engineering optimization on a set of self-powering triboelectric nanogenerator ... -
A Flexible, Robust Microbead-based Assay for Quantification and Normalization of Target Protein Concentrations
There are many methods for quantifying the concentration of a specific (target) protein in a sample, but current techniques are technically challenging or do not easily lend themselves to normalizing measured protein ... -
Metadata Analysis of Astrocytic Regulatory Compensation in SOD1-G93A Amyotrophic Lateral Sclerosis Mouse Model
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease characterized by progressive degradation of motoneurons in the central nervous system (CNS). Astrocytes are key regulators for inflammation and neuromodulatory ... -
Multi-factorial treatment paradigm detection could be the answer to complex diseases: a case study of ALS
Amyotrophic Lateral Sclerosis (ALS) is a debilitating neurodegenerative disease with no known cause or cure. Through a combination of an open market-space, scientific curiosity, and the humanitarian motivation to advance ... -
An Analysis of Quality of Life (QOL) and Survival Impact in Amyotrophic Lateral Sclerosis (ALS) Patients
In neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS), quality of life (QOL) – a patient’s ability and desire to lead a fulfilling life – is an important measure to determine disease evolution and ...
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