Department of Biomedical Engineering Undergraduate Research Option Theses
The Research Option offers students majoring in biomedical engineering the opportunity for a substantial, in-depth research experience. Students are strongly encouraged at the end of their experience to work with their faculty mentor to develop a journal publication or conference presentation on the research in addition to the actual thesis.
All materials in SMARTech are protected under U.S. Copyright Law and all rights are reserved. Such materials may be used, quoted or reproduced for educational purposes only with prior permission, provided proper attribution is given. Any redistribution, reproduction or use of the materials, in whole or in part, is prohibited without prior permission of the author.
Recent Submissions
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The effects of AT-RvD1 delivery on SPM metabolism, myeloid recruitment, and myogenesis in a murine model of Volumetric Muscle Loss injury
Volumetric Muscle Loss injury (VML) is the partial ablation of skeletal muscle, usually on the extremities, sustained through traumatic or surgical means, such as motor vehicle accidents, military combat, or surgical ... -
Differentiation and Proliferation of Therapeutic T cells from umbilical cord blood derived cells
Cancer is among the leading causes of death worldwide; in 2018, there were 18.1 million new cases and 9.5 million cancer-related deaths. Current methods, such as chemotherapy, have been used for decades and while it is a ... -
An Anti-Influenza Strategy Based on siRNA Approach Targeting the Critical Viral and Host Factors
The influenza virus remains a major public health concern causing significant morbidity and mortality in humans. Vaccination is considered the most effective prevention strategy as antivirals are suboptimal in treating the ... -
The role of action observation in prosthesis learning
When portions of upper limbs are lost, persons with new amputations must re-learn how to exist within the world. This involves training patients on prosthetic devices that aim to replace limb functionality; however, these ... -
Providing Proprioceptive Feedback Via A Simultaneous Skin Stretch And Vibrotactile Haptic Display
This paper presents the development and testing of a non-invasive haptic display that will provide proprioceptive information to a user about the location of the prosthetic device. This is accomplished using a previously ... -
Modeling Aortic Valvular Leaflet Thrombosis Risk Following Transcatheter Aortic Valve Replacement
Calcific aortic stenosis (AS) is the thickening of the aortic valve leaflets in the heart due to calcium buildup. Currently, the most widespread treatment option is transcatheter aortic valve replacement (TAVR), a minimally ... -
MACHINE LEARNING MODELING OF COVID-19 AND CORONARY HEART DISEASE FOR PUBLIC HEALTH MONITORING AND CLINICAL DECISION SUPPORT
Prediction of healthcare trends to improve public health and clinical decision making is a challenge affecting all lives and requires state-of-art mathematical modeling to solve. The use of artificial intelligence (AI) in ... -
Rapid Multiplexing of Proteins for Deciphering Spatially Resolved Biophysical Organelle Networks
Organelles play important roles in human health and disease, such as maintaining homeostasis, regulating growth and aging, and generating energy. Organelle diversity in cells not only exists between cell types but also ... -
The Biomechanics of Elephant Trunk Elongation
The elephant trunk is one of the largest, most versatile boneless appendages, dwarfing similar muscular hydrostats such as octopus tentacles and chameleon tongues. Little is known about how an elephant’s large size influences ... -
3D Culture of Mesenchymal Stem Cells in PEG-4MAL Hydrogels Increases Exosome Production with Bacterial Sphingomyelinase Treatment
Exosomes are becoming increasingly popular in the fields of regenerative medicine and tissue engineering for their immunomodulatory potential to enhance tissue regeneration. Exosomes are a membrane-bound extracellular ... -
Timing of the Protective Effect of Photopic Lighting on Treating Myopia
Purpose. Photopic lighting reduces myopia severity in animal and human studies. However, the causal relationship identified in past animal studies have pre-treated the animals with photopic lighting prior to myopia ... -
Development of a microscale aqueous two-phase system bacterial culture platform
Development of a bacterial culture platform which accounts for the characteristic human gut oxygen gradient could allow for improved understanding of the gut microbiome and its implications in human health as well as ... -
Generation of T cell lines expressing wild type and mutant CD3ε FRET sensors and characterization of CD3ε regulation by plasma membrane binding
T cells are a crucial part of our adaptive immune response by protecting our system against pathogens and cancer. They recognize specific foreign peptides on the surface of antigen presenting cells (APC) through T cell ... -
Synthetic Nanoparticle Antibodies as an Immunomodulatory Strategy for Musculoskeletal Trauma
Approximately 6 million bone fractures are reported annually within the US, 10% of which may experience complications, such as nonunion (permanent failure to heal) or delayed healing. These complications often result in ... -
The Effect of Heterofunctional Microparticles on Identifying High Producing CHO cells
Antibodies are produced by the human body in response to a foreign antigen such as a virus, parasite, and bacteria. Sometimes, the immune system fails to make enough antibodies to combat disease so man made monoclonal ... -
Evaluating Various Whole-Mount Organoid Tissue Clearing Techniques for High Throughput Experimentation with Microfluidics
Originating from human pluripotent stem cells, organoids are three-dimensional structures that resemble the developing human brain. These multicellular structures are capable of recapitulating distinct features of organ ... -
The Role of Noise-Induced Excitable Dynamics of Rho Family GTPases in the Regulation of Actin Cytoskeleton
Rho GTPases, a family of signaling proteins, play a pivotal role by acting as molecular switches to regulate F-actin cytoskeletal and cell adhesion. Recent studies have shown that reaction-diffusion (RD) models have the ... -
Additive Manufacturing for the Design of an Adjustable Putter
In golf, there is use for a putter which can be customized to fit a golfer’s need on a given day. By adjusting the openness of the club, known as toe-hang, the angle of the face, known as loft, and the surface material of ... -
Validation Testing of Multiple IMUs as Sensors of Joint Angles
Hip flexion angles were measured on a subject for both walking and sprinting trials using two different IMUs: Microstrain’s IMU and Adafruit’s BNO055 IMU. These measurements were compared against measurements simultaneously ... -
Biomechanical Characterization of the Human Tricuspid Apparatus
Tricuspid regurgitation is a form of cardiovascular illness that affects over 1.6 million people in the United States. This condition is more often discovered once it becomes symptomatic, which is usually much too late in ...
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