Biomolecular Materials That Talk and Listen

Show simple item record Stayton, Patrick S. 2009-07-20T19:20:55Z 2009-07-20T19:20:55Z 2002-10-10
dc.description Pat Stayton of the University of Washington Department of Bioengineering presented a lecture on October 10, 2002 at 11:00 am in the Suddath Seminar Room, IBB Building, Georgia Tech Campus. en
dc.description.abstract "Smart" or "intelligent" materials are those that reversibly change their structural and functional properties in response to environmental signals such as a change in temperature. Nature has itself perfected smart polymers in the form of proteins. A hallmark of many proteins is their ability to change their structural and functional properties in response to specific physical changes. That they can do this reversibly, in a continuously cyclical fashion, is a remarkable materials property. The molecular mechanisms that proteins use to sense and respond provide interesting paradigms for the development of new smart polymer based biotechnologies. As with nature and proteins, we have been working to develop systems where the environmentally responsive changes in polymer structure and physical properties are directly coupled to biofunctionality. These biofunctional smart polymers provide "listening" elements that reversibly modulate protein (or other biomolecules) activity in the device setting. Other biofunctional smart polymers are designed to directly enhance intracellular trafficking of biomolecular therapeutics, by destabilizing biological membranes in response to compartmental pH changes. In this talk, I will provide an overview of hybrid polymer biomolecule systems that are designed for applications in gene and protein delivery, diagnostics, microfluidics, and chip/array biotechnologies. These systems merge the impressive recognition and biofunctional properties of biomolecules, with the impressive responsiveness and chemical versatility of functional polymers. en
dc.language.iso en_US en
dc.publisher Georgia Institute of Technology en
dc.subject Smart polymers en
dc.subject Smart biomaterials en
dc.subject Drug delivery en
dc.subject Gene and protein delivery en
dc.subject Protein engineering en
dc.subject Tissue engineering
dc.title Biomolecular Materials That Talk and Listen en
dc.type Lecture en
dc.type Video en
dc.contributor.corporatename Georgia Institute of Technology. Institute for Bioengineering and Bioscience
dc.contributor.corporatename University of Washington. Dept. of Bioengineering

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