The Nanoscale Biointerface and Healing Biomaterials
Ratner, Buddy D.
MetadataShow full item record
Implantable medical devices, and the biomaterials that comprise them, are measured on macro scales (centimeters). Yet the biocompatibility of such devices may be dictated by phenomena best described at nanometer dimensions. Biomedical implants and the University of Washington Engineered Biomaterials (UWEB) Engineering Research Center will be introduced. The classical definition of biocompatibility will be contrasted to a newer definition embracing nanomolecular concepts. Biological data on the in vivo healing responses of mammals to matricellular proteins such as osteopontin, thrombospondin 2 and SPARC will be presented with an emphasis on exploiting the special reactivity of such proteins. First, non-specific protein adsorption must be inhibited. Strategies to achieve this design parameter will be presented. Then methods to deliver the specific protein signals will be addressed. An imprinting approach and a self-assembly approach will be described. Finally, speculation on how such materials that precisely control interfacial biological reactions will be used in medicine will complete this lecture. Modern surface analysis techniques that can address the complexity of a functional biointerface will be highlighted to define nanostructures.