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dc.contributor.authorIdaghdour, Youssefen_US
dc.contributor.authorStorey, John D.en_US
dc.contributor.authorJadallah, Sami J.en_US
dc.contributor.authorGibson, Gregen_US
dc.date.accessioned2009-12-09T21:04:07Z
dc.date.available2009-12-09T21:04:07Z
dc.date.issued2008-04-11
dc.identifier.citationIdaghdour Y., Storey J.D., Jadallah S.J., Gibson G., (2008) A Genome-Wide Gene Expression Signature of Environmental Geography in Leukocytes of Moroccan Amazighs. PLoS Genet 4(4): e1000052. doi:10.1371/journal.pgen.1000052en
dc.identifier.issn1553-7390
dc.identifier.urihttp://hdl.handle.net/1853/31347
dc.description© 2008 Idaghdour et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.descriptionDOI: 10.1371/journal.pgen.1000052
dc.description.abstractThe different environments that humans experience are likely to impact physiology and disease susceptibility. In order to estimate the magnitude of the impact of environment on transcript abundance, we examined gene expression in peripheral blood leukocyte samples from 46 desert nomadic, mountain agrarian and coastal urban Moroccan Amazigh individuals. Despite great expression heterogeneity in humans, as much as one third of the leukocyte transcriptome was found to be associated with differences among regions. Genome-wide polymorphism analysis indicates that genetic differentiation in the total sample is limited and is unlikely to explain the expression divergence. Methylation profiling of 1,505 CpG sites suggests limited contribution of methylation to the observed differences in gene expression. Genetic network analysis further implies that specific aspects of immune function are strongly affected by regional factors and may influence susceptibility to respiratory and inflammatory disease. Our results show a strong genome-wide gene expression signature of regional population differences that presumably include lifestyle, geography, and biotic factors, implying that these can play at least as great a role as genetic divergence in modulating gene expression variation in humans.en
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen
dc.subjectImpact of environment on transcript abundanceen
dc.subjectLeukocyte transcriptomeen
dc.subjectGenetic network analysisen
dc.subjectRegional factorsen
dc.subjectImmune functionen
dc.titleA Genome-Wide Gene Expression Signature of Environmental Geography in Leukocytes of Moroccan Amazighsen
dc.typeArticleen
dc.contributor.corporatenameNorth Carolina State Universityen_US
dc.contributor.corporatenamePrinceton Universityen_US
dc.contributor.corporatenameInternational Foundation for Conservation & Development of Wildlifeen_US
dc.contributor.corporatenameUniversity of Queenslanden_US
dc.publisher.originalPublic Library of Science
dc.identifier.doi10.1371/journal.pgen.1000052


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