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dc.contributor.authorKim, Seong-Hoen_US
dc.contributor.authorElango, Navinen_US
dc.contributor.authorWarden, Charles Daviden_US
dc.contributor.authorVigoda, Ericen_US
dc.contributor.authorYi, Soojin V.en_US
dc.date.accessioned2009-12-11T19:55:52Z
dc.date.available2009-12-11T19:55:52Z
dc.date.issued2006-10-06
dc.identifier.citationCitation: Kim S-H, Elango N, Warden C, Vigoda E, Yi SV (2006) Heterogeneous Genomic Molecular Clocks in Primates. PLoS Genet 2(10): e163. doi:10.1371/journal.pgen.0020163en
dc.identifier.issn1553-7390
dc.identifier.urihttp://hdl.handle.net/1853/31378
dc.descriptionCopyright: © 2006 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en
dc.descriptionDOI: 10.1371/journal.pgen.0020163
dc.description.abstractUsing data from primates, we show that molecular clocks in sites that have been part of a CpG dinucleotide in recent past (CpG sites) and non-CpG sites are of markedly different nature, reflecting differences in their molecular origins. Notably, single nucleotide substitutions at non-CpG sites show clear generation-time dependency, indicating that most of these substitutions occur by errors during DNA replication. On the other hand, substitutions at CpG sites occur relatively constantly over time, as expected from their primary origin due to methylation. Therefore, molecular clocks are heterogeneous even within a genome. Furthermore, we propose that varying frequencies of CpG dinucleotides in different genomic regions may have contributed significantly to conflicting earlier results on rate constancy of mammalian molecular clock. Our conclusion that different regions of genomes follow different molecular clocks should be considered when inferring divergence times using molecular data and in phylogenetic analysis.en
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen
dc.subjectMutationsen
dc.subjectMolecular clocken
dc.subjectMolecular evolutionen
dc.subjectMethylation-origin mutationsen
dc.subjectReplication-origin mutationsen
dc.subjectPhylogenetic analysesen
dc.titleHeterogeneous Genomic Molecular Clocks in Primatesen
dc.typeArticleen
dc.contributor.corporatenameGeorgia Institute of Technology. School of Biologyen_US
dc.contributor.corporatenameGeorgia Institute of Technology. College of Computingen_US
dc.publisher.originalPublic Library of Science
dc.identifier.doi10.1371/journal.pgen.0020163


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