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dc.contributor.authorPetrov, Anton S.en_US
dc.contributor.authorLocker, C. Rebeccaen_US
dc.contributor.authorHarvey, Stephen C.en_US
dc.date.accessioned2010-01-12T18:46:21Z
dc.date.available2010-01-12T18:46:21Z
dc.date.issued2009-08
dc.identifier.citationAnton S. Petrov, C. Rebecca Locker, and Stephen C. Harvey, "Characterization of DNA conformation inside bacterial viruses," Phys. Rev. E 80, 021914 (2009)
dc.identifier.issn1539-3755
dc.identifier.urihttp://hdl.handle.net/1853/31458
dc.description©2009 The American Physical Society. The electronic version of this article is the complete one and can be found online at: http://link.aps.org/doi/10.1103/PhysRevE.80.021914en
dc.descriptionDOI:10.1103/PhysRevE.80.021914
dc.description.abstractIn this study we develop a formalism to describe the organization of DNA inside bacteriophage capsids during genome packaging. We have previously shown that DNA inside bacteriophage phi29 (ϕ29) is organized into folded toroids [A. S. Petrov and S. C. Harvey, Structure 15, 21 (2007)], whereas epsilon15 (ε15) reveals the coaxial organization of the genetic material [A. S. Petrov, K. Lim-Hing, and S. C. Harvey, Structure 15, 807 (2007)]. We now show that each system undergoes two consecutive transitions. The first transition corresponds to the formation of global conformations and is analogous to a disorder-order conformational transition. The second transition is characterized by a significant loss of DNA mobility at the local level leading to glasslike dynamic behavior. Packing genetic material inside bacteriophages can be used as a general model to study the behavior of semiflexible chains inside confined spaces, and the proposed formalism developed here can be used to study other systems of linear polymer chains confined to closed spaces.en
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen
dc.subjectBacteriophages
dc.subjectBacterioviruses
dc.subjectCapsids
dc.subjectFolded toroids
dc.subjectGenome packaging
dc.titleCharacterization of DNA conformation inside bacterial virusesen
dc.typeArticleen
dc.contributor.corporatenameGeorgia Institute of Technology. School of Biologyen_US
dc.publisher.originalAmerican Physical Society
dc.identifier.doi10.1103/PhysRevE.80.021914


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