Browsing School of Applied Physiology Theses and Dissertations by Issue Date
Now showing items 1-20 of 28
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Mechanisms and implications of sodium loss in sweat during exercise in the heat for patients with cystic fibrosis and healthy individuals
(Georgia Institute of Technology, 2009-11-17)Our aim was to understand mechanisms responsible for excessive electrolyte loss in the sweat gland and the potential impact on fluid balance during exercise in heat stress conditions. Human physiological testing under ... -
Robustness and hierarchical control of performance variables through coordination during human locomotion
(Georgia Institute of Technology, 2010-11-03)The kinematic motor redundancy of the human legs provides more local degrees of freedom than are necessary to achieve low degree of freedom performance variables like leg length and orientation. The purpose of this ... -
Motor learning and its transfer during bilateral arm reaching.
(Georgia Institute of Technology, 2011-06-09)Have you ever attempted to rub your abdomen with one hand while tapping your head with the other? Separately these movements are easy to perform but doing them together (bilateral task) requires motor adaptation. Motor ... -
Motor control in persons with a trans-tibial amputation during cycling
(Georgia Institute of Technology, 2011-07-06)Motor control of any movement task involves the integration of neural, muscular and skeletal systems. This integration must occur throughout the sensorimotor system and focus its efforts on controlling the system endpoint, ... -
Regulation of the cardiac isoform of the ryanodine receptor by S-adenosyl-l-methionine
(Georgia Institute of Technology, 2011-11-08)Activity of the Ryanodine Receptor (RyR2) (aka cardiac Ca2+ release channel) plays a pivotal role in contraction of the heart. S-adenosyl-l-methionine (SAM) is a biological methyl group donor that has close structural ... -
Mechanical and metabolic stresses contribute to high force contraction signaling
(Georgia Institute of Technology, 2012-03-27)Force production by a muscle is critical to maintaining proper function and overall health of a human or animal. Muscle adapts to increased loading with hypertrophy by activating a number of intracellular signaling cascades ... -
Injury compensation reveals implicit goals that guide locomotor coordination
(Georgia Institute of Technology, 2012-04-08)Locomotion persists despite changes in external and internal circumstances. Motor responses to gait impairment exhibit commonalities across various taxa and types of injury, yet we lack a systematic understanding of ... -
Dynamic stability of quadrupedal locomotion: animal model, cortical control and prosthetic gait
(Georgia Institute of Technology, 2012-11-13)The ability to control balance and stability are essential to prevent falls during locomotion. Maintenance of stable locomotion is challenging especially when complicated by amputation and prosthesis use. Humans employ ... -
Task dependent effects of baroreceptor unloading on motor cortical and corticospinal pathways
(Georgia Institute of Technology, 2013-08-27)Corticospinal and intracortical excitability are excitability measures of the central nervous system responsible for motor generation, and are studied for their contribution to fine motor skill execution and learning. ... -
The acute effects of physical activity on the stiffness of the plantar skin of people with and without diabetes
(Georgia Institute of Technology, 2013-11-18)Diabetes affects 25.8 million Americans. Complications related to this growing disease impact public health. One secondary complication of diabetes is changes in skin that can contribute to an increased risk for ulceration. ... -
Promoting enhanced motor planning in prosthesis users via matched limb imitation
(Georgia Institute of Technology, 2014-03-13)As of 2005, there were over 1.5 million amputees living in the United States, more than 548,000 of them with upper extremity involvement. The total number of amputees is projected to rise to at least 2.2 million by 2020. ... -
Adaptation of locomotor control in able and impaired human walking
(Georgia Institute of Technology, 2014-06-13)Extensive research has documented the stereotypical kinematic and kinetic patterns in healthy human walking, but we have a limited understanding of the neuromechanical control principles that contribute to their execution. ... -
Fatigue mechanisms in sedentary and endurance trained adults: effects of nutritional countermeasures
(Georgia Institute of Technology, 2015-04-08)Physical inactivity is a major risk factor for chronic disease; yet the majority of the population does not meet physical activity recommendations, with fatigue being a primary underlying reason. Common nutritional supplements ... -
Understanding the neurophysiology of action interpretation in right and left-handed individuals
(Georgia Institute of Technology, 2015-04-08)Investigating the neurophysiology behind our action encoding system offers a way of probing the underlying mechanisms regarding how we understand seen action. The ability to mentally simulate action (motor simulation) is ... -
Influencing motor behavior through constraint of lower limb movement
(Georgia Institute of Technology, 2015-04-29)Limited knowledge of the neuromechanical response to use of an ankle foot orthosis-footwear combination (AFO-FC) has created a lack of consensus in understanding orthotic motion control as a therapeutic treatment. Lack of ... -
Altered intermuscular force feedback after spinal cord injury in cat
(Georgia Institute of Technology, 2015-07-24)Bipeds and quadrupeds are inherently unstable and their bodies sway during quiet stance and require complex patterns of muscle activation to produce direction-specific forces to control the body’s center of mass. The ... -
Neuromechanics of locomotion: Insights from the walk-to-run transition in amputees and pedaling in able-bodied individuals
(Georgia Institute of Technology, 2015-10-16)Afferent feedback is important for modulating locomotion and maintaining stability. Studying locomotor extremes and applying perturbations to normal locomotion allows us to probe the effects of afferent feedback on the ... -
Spatiotemporal patterns of parietofrontal activity and eye movements underlying the visual perception of complex human tool use
(Georgia Institute of Technology, 2015-11-16)When watching a child learning to use a spoon, a mother is immediately able to recognize the error when the child grabs the bowl rather than the stem, or when the child uses the spoon to try and scoop paper. Recognizing ... -
Substrate-level control of glucose metabolism in C2C12 myotubes
(Georgia Institute of Technology, 2016-03-30)Metabolic flexibility is critical for muscle to maintain proper function and overall health. Muscle adapts to metabolic stress with increasing ATP synthesis by enhancing the rate of glycolysis and mitochondrial respiration. ... -
Mechanisms of coordination between one- and two-joint synergist muscles
(Georgia Institute of Technology, 2016-04-15)Major muscle groups (e.g. triceps surae, quadriceps, hamstrings, triceps brachii) contain synergist muscles that cross either one or two joints; they are called one- and two-joint muscles. The functional significance of ...