The Undergraduate Research Kaleidoscope Fall 2010

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dc.contributor.author Chen, Michael
dc.date.accessioned 2011-03-30T20:33:22Z
dc.date.available 2011-03-30T20:33:22Z
dc.date.issued 2010-11-18
dc.identifier.uri http://hdl.handle.net/1853/38340
dc.description A presentation in the Undergraduate Research Kaleidoscope: Library East Commons Performance Space, November 18, 2010. en_US
dc.description Runtime: 07:30 minutes. en_US
dc.description.abstract Individuals suffering from Friedrich’s ataxia, a neuromuscular hereditary disease, have expansions of the DNA triplet repeat GAA/TTC in their genomic DNA. Preliminary investigations into the disease point to the ability of triplet repeats to adopt unusual DNA structures, such as matched and mismatched triplexes. This paper presents a novel method to probe the secondary structure of nucleic acids with the binding specificity of ligands called intercalators. In previous studies, the type of nucleic acid structure an intercalator binds to is dependent on the chemical identity and molecular shape of the intercalator. Using this selectivity, azacyanines “shown to target the in vivo structure that GAA/TTC triplet repeats form” will be combined with nucleic acids of various known structures. The nucleic acid structure that azacyanine has the highest affinity for will most likely be the structure of the GAA/TTC triplet repeat. The discovery of the structure that causes DNA triplet repeat disorders could lead to the development of novel therapeutic treatments. en_US
dc.format.extent 07:30 minutes
dc.language.iso en_US en
dc.publisher Georgia Institute of Technology en
dc.subject URK en
dc.subject Undergraduate research en
dc.subject Triplet DNA repeat disorders en
dc.subject Intercalation en
dc.subject Friedreich's ataxia en
dc.title The Undergraduate Research Kaleidoscope Fall 2010 en
dc.type Presentation en
dc.type Video en
dc.contributor.corporatename Georgia Institute of Technology. Undergraduate Research Opportunities Program
dc.contributor.corporatename Georgia Institute of Technology. Library and Information Center
dc.contributor.corporatename Georgia Institute of Technology. School of Chemistry and Biochemistry
dc.contributor.corporatename Georgia Institute of Technology. Honors Program


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