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dc.contributor.authorChen, Michael
dc.date.accessioned2011-03-30T20:33:22Z
dc.date.available2011-03-30T20:33:22Z
dc.date.issued2010-11-18
dc.identifier.urihttp://hdl.handle.net/1853/38340
dc.descriptionA presentation in the Undergraduate Research Kaleidoscope: Library East Commons Performance Space, November 18, 2010.en_US
dc.descriptionRuntime: 07:30 minutes.en_US
dc.description.abstractIndividuals suffering from Friedrich’s ataxia, a neuromuscular hereditary disease, have expansions of the DNA triplet repeat GAA/TTC in their genomic DNA. Preliminary investigations into the disease point to the ability of triplet repeats to adopt unusual DNA structures, such as matched and mismatched triplexes. This paper presents a novel method to probe the secondary structure of nucleic acids with the binding specificity of ligands called intercalators. In previous studies, the type of nucleic acid structure an intercalator binds to is dependent on the chemical identity and molecular shape of the intercalator. Using this selectivity, azacyanines “shown to target the in vivo structure that GAA/TTC triplet repeats form” will be combined with nucleic acids of various known structures. The nucleic acid structure that azacyanine has the highest affinity for will most likely be the structure of the GAA/TTC triplet repeat. The discovery of the structure that causes DNA triplet repeat disorders could lead to the development of novel therapeutic treatments.en_US
dc.format.extent07:30 minutes
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen
dc.subjectURKen
dc.subjectUndergraduate researchen
dc.subjectTriplet DNA repeat disordersen
dc.subjectIntercalationen
dc.subjectFriedreich's ataxiaen
dc.titleThe Undergraduate Research Kaleidoscope Fall 2010en
dc.typePresentationen
dc.typeVideoen
dc.contributor.corporatenameGeorgia Institute of Technology. Undergraduate Research Opportunities Program
dc.contributor.corporatenameGeorgia Institute of Technology. Library and Information Center
dc.contributor.corporatenameGeorgia Institute of Technology. School of Chemistry and Biochemistry
dc.contributor.corporatenameGeorgia Institute of Technology. Honors Program


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