Finding Evidence of a Cancer Suppressing Mutation, rs 3814113
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For the past twenty years ovarian cancers has been one of the most well studied cancers. While many aspects of ovarian cancer are understood, scientists do not know what mutations cause tumor genesis. In recent years scientists have turned to genome wide association studies(GWAS) to determine what mutations are correlated to the disease, but these studies have not provided sufficient evidence to produce establish a causal link between a mutation and the disease. Instead of trying to create larger studies, scientists need to perform more focused smaller studies such as this one. This study will be investigating the findings of a recent GWAS performed by Dr. Song and his associates. However, instead of investigating the genetic information of thousands of individuals this study will focus on the complete profile of a twenty patients. This study will differ by including factors such as the patient and familial history of each of the cancer cases. By investigating this additional information this study will either prove or disprove the correlation between the SNP rs3814113 and ovarian cancer. after investigating genotypic ratios, onset of the disease, and risk ratios among pathological and genotypic groups this study found no evidence to support rs 3814113 as a cancer suppressing mutation.