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dc.contributor.authorPlatt, Manu O.
dc.date.accessioned2011-09-26T15:57:11Z
dc.date.available2011-09-26T15:57:11Z
dc.date.issued2011-09-13
dc.identifier.urihttp://hdl.handle.net/1853/41234
dc.descriptionPresented on September 13, 2011 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering & Bioscience (IBB), room 1128, Georgia Tech.en_US
dc.descriptionRuntime: 52:51 minutes
dc.description.abstractCathepsins are enzymes with the most powerful human collagenase and elastase activity that are upregulated at sites of normal tissue remodeling and during tissue-destructive disease progression. We study them in the context of tissue remodeling in cancer progression and cardiovascular diseases such as sickle cell disease and atherosclerosis. They are synthesized as stable inactive precursors requiring activation by propeptide cleavage, and detection of mature cathepsins and quantification of specific activity have proven difficult due to instability of the mature, active enzyme extracellularly, diminishing appreciation for their involvement in a large number of diseases. During this seminar, we will discuss our studies of this family of powerful proteases in diseases with particular attention to cancer and sickle cell disease. First, we will discuss the important development of a reliable, sensitive method of zymography to detect the activity of mature cathepsins K, L, S, and V and integrating that assay with the development of a computational kinetic model to predict cathepsin-mediated tissue remodeling by cells during advancing disease. Secondly, we will discuss our applications of these technologies and potential use as both diagnostic and prognostic indicators of human breast, lung, and cervical cancer as well as newly identified mechanisms of cathepsin activity in complications of stroke in children with sickle cell disease.en_US
dc.format.extent52:51 minutes
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.relation.ispartofseriesPetit Institute Breakfast Club Seminar Series
dc.subjectCanceren_US
dc.subjectDetectionen_US
dc.subjectEnzymesen_US
dc.subjectHIVen_US
dc.subjectSickle cellen_US
dc.title“What’s Eating You?” Quantifying Proteolytic Activity in Health and Disease with Novel Assays and Computational Modelsen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Institute for Bioengineering and Bioscience
dc.contributor.corporatenameGeorgia Institute of Technology. Dept. of Biomedical Engineering


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