Protein Folding Inside Cells and Other Crowded Environments

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Title: Protein Folding Inside Cells and Other Crowded Environments
Author: Gruebele, Martin
Abstract: Computer simulations are reaching the point where folding of small proteins in vitro can be successfully achieved ‘ab initio’ by molecular dynamics. Experiments can help further calibrate simulations, and I will discuss two examples. Experiments can also move forward to study protein dynamics in complex environment, such as the interior of the cell. There, modulation of the energy landscape and local viscosity can affect protein stability and folding kinetics. I will discuss experimental examples. The ultimate question, which cannot be answered yet, is whether cells evolved to gainfully modulate protein landscapes after post translational folding and modification, or whether microenvironments in the cell just provide stochastic modulation.
Description: Martin Gruebele, James R. Eiszner Endowed Chair in Chemistry; Professor of Physics and Center for Biophysics and Computational Biology at the University of Illinois at Urbana-Champaign, presented a lecture on Tuesday, November 8, 2001 at 11 am in Room 1116E of the Klaus Advanced Computing Building on the Georgia Tech campus. Runtime: 64:38 minutes
Type: Lecture
Date: 2011-11-08
Contributor: University of Illinois at Urbana-Champaign
Georgia Institute of Technology. Center for the Study of Systems Biology
Georgia Institute of Technology. School of Biology
Publisher: Georgia Institute of Technology
Subject: Biophysics
Protein folding
Fluorescence microscopy

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