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dc.contributor.authorZhao, Hongshi
dc.contributor.authorWang, Guancong
dc.contributor.authorHu, Shunpeng
dc.contributor.authorCui, Jingjie
dc.contributor.authorRen, Na
dc.contributor.authorLiu, Duo
dc.contributor.authorLiu, Hong
dc.contributor.authorCao, Chengbo
dc.contributor.authorWang, Jiyang
dc.contributor.authorWang, Z. L. (Zhong Lin)
dc.date.accessioned2011-12-06T20:26:21Z
dc.date.available2011-12-06T20:26:21Z
dc.date.issued2011-02-26
dc.identifier.citationHongshi Zhao, Guancong Wang, Shunpeng Hu, Jingjie Cui, Na Ren, Duo Liu, Hong Liu, Chengbo Cao, Jiyang Wang, and Zhonglin Wang, ”In vitro Biomimetic Construction of Hydroxyapatite–Porcine Acellular Dermal Matrix Composite Scaffold for MC3T3-E1 Preosteoblas,“ Tissue Engineering Part A, 2011, 17, 5-6.en
dc.identifier.issn1076-3279
dc.identifier.urihttp://hdl.handle.net/1853/42069
dc.descriptionThis is a copy of an article published in Tissue Engineering Part A ©2011 Mary Ann Liebert, Inc.; Tissue Engineering Part A is available online at: http://www.liebertonline.com.en
dc.descriptionDOI: 10.1089/ten.tea.2010.0196
dc.description.abstractThe application of porous hydroxyapatite–collagen (HAp-Collagen) as a bone tissue engineering scaffold is hindered by two main problems: its high cost and low initial strength. As a native 3-dimenssional collagen framework, purified porcine acellular dermal matrix (PADM) has been successfully used as a skin tissue engineering scaffold. Here we report its application as a matrix for the preparation of HAp to produce a bone tissue scaffold through a biomimetic chemical process. The HAp-PADMscaffold has two-level pore structure, with large channels (*100 mm in diameter) inherited from the purified PADM microstructure and small pores (<100 nm in diameter) formed by self-assembled HAp on the channel surfaces. The obtained HAp-PADM scaffold (S15D) has a compressive elastic modulus as high as 600 kPa. The presence of HAp in sample S15D reduces the degradation rate of PADM in collagenase solution at 378C. After 7 day culture of MC3T3-E1 pre-osteroblasts, MTT data show no statistically significant difference on pure PADM framework and HAp-PADM scaffold ( p>0.05). Because of its high strength and nontoxicity, its simple preparation method, and designable and tailorable properties, the HAp- PADM scaffold is expected to have great potential applications in medical treatment of bone defects.en
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen
dc.subjectBiomedical bone implantsen
dc.subjectBone defectsen
dc.subjectBone tissue engineering scaffolden
dc.subjectPorcine acellular dermal matrixen
dc.subjectPADMen
dc.titleIn vitro Biomimetic Construction of Hydroxyapatite–Porcine Acellular Dermal Matrix Composite Scaffold for MC3T3-E1 Preosteoblast Cultureen
dc.typeArticleen
dc.contributor.corporatenameShandong University. State Key Laboratory of Crystal Materials
dc.contributor.corporatenameShandong University. Center of Bio and Micro/Nano Functional Materials
dc.contributor.corporatenameShandong University. School of Physics and Microelectronics
dc.contributor.corporatenameShandong University. School of Chemistry and Chemical Engineering
dc.contributor.corporatenameGeorgia Institute of Technology. School of Materials Science and Engineering
dc.publisher.originalMary Ann Liebert, Inc.


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