Influence of Surface Chemistry on Microtextured Titanium on the Osteoblast Cell Response
Park, Jung Hwa
MetadataShow full item record
The aim of this study was to examine the possibility to increased surface wettability of microstructured Ti surfaces through polyelectrolyte modifications without changing surface microstructure and whether these chemical modifications alter osteoblast maturation. Polyelectrolytes [chitosan (CHI), poly(L-glutamic acid) (PGA), and poly(L-lysine) (PLL)] were used to coat Ti surfaces with different surface roughness (PT, Ra ≤ 0.4 μm and SLA, Ra > 3.5 μm). Surfaces were characterized using X-ray photoelectron spectroscopy, scanning electron microscopy, profilometry, and contact angle. MG63 osteoblast-like cells were cultured on uncoated or the chemically-modified surfaces. At confluence, cells number, alkaline phosphatase specific activity, and osteocalcin levels were analyzed. The polyelectrolyte modifications increased surface wettability without changing surface microstructure. This change had effect on osteoblast differentiation which was material dependent.
- Nano@Tech Lecture Series