Show simple item record

dc.contributor.authorMissmer, Stacey A.en_US
dc.contributor.authorSuarez, Lucinaen_US
dc.contributor.authorFelkner, Marilynen_US
dc.contributor.authorWang, Elaineen_US
dc.contributor.authorMerrill, Alfred H.en_US
dc.contributor.authorRothman, Kenneth J.en_US
dc.contributor.authorHendricks, Katherine A.en_US
dc.date.accessioned2012-01-06T19:40:58Z
dc.date.available2012-01-06T19:40:58Z
dc.date.issued2005-09-25
dc.identifier.citationStacey A. Missmer, Lucina Suarez, Marilyn Felkner, Elaine Wang, Alfred H. Merrill, Jr., Kenneth J. Rothman, and Katherine A. Hendricks, “Exposure to Fumonisins and the Occurrence of Neural Tube Defects along the Texas–Mexico Border,” Environ Health Perspect. 2006 February; 114(2): 237–241en_US
dc.identifier.issn0091-6765
dc.identifier.urihttp://hdl.handle.net/1853/42168
dc.descriptionReproduced with permission from Environmental Health Perspectivesen_US
dc.descriptionDOI: 10.1289/ehp.8221
dc.descriptionThe definitive version of this article is available at : http://dx.doi.org/10.1289/ehp.8221
dc.description.abstractAlong the Texas-Mexico border, the prevalence of neural tube defects (NTDs) among Mexican-American women doubled during 1990-1991. The human outbreak began during the same crop year as epizootics attributed to exposure to fumonisin, a mycotoxin that often contaminates corn. Because Mexican Americans in Texas consume large quantities of corn, primarily in the form of tortillas, they may be exposed to high levels of fumonisins. We examined whether or not maternal exposure to fumonisins increases the risk of NTDs in offspring using a population-based casecontrol study. We estimated fumonisin exposure from a postpartum sphinganine:sphingosine (sa:so) ratio, a biomarker for fumonisin exposure measured in maternal serum, and from maternal recall of periconceptional corn tortilla intake. After adjusting for confounders, moderate (301400) compared with low 100) consumption of tortillas during the first trimester was associated with increased odds ratios (ORs) of having an NTD-affected pregnancy (OR = 2.4; 95% confidence interval, 1.15.3). No increased risks were observed at intakes higher than 400 tortillas (OR = 0.8 for 401800, OR = 1.0 for > 800). Based on the postpartum sa:so ratio, increasing levels of fumonisin exposure were associated with increasing ORs for NTD occurrences, except for the highest exposure category (sa:so > 0.35). Our findings suggest that fumonisin exposure increases the risk of NTD, proportionate to dose, up to a threshold level, at which point fetal death may be more likely to occur. These results also call for population studies that can more directly measure individual fumonisin intakes and assess effects on the developing embryo.en
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen
dc.subjectCase–control studyen
dc.subjectCornen
dc.subjectFumonisinsen
dc.subjectMexican Americansen
dc.subjectMycotoxinsen
dc.titleExposure to fumonisins and the occurrence of neural tube defects along the Texas-Mexico borderen
dc.typeArticleen
dc.contributor.corporatenameHarvard School of Public Health. Dept. of Epidemiologyen_US
dc.contributor.corporatenameBrigham and Women’s Hospital. Dept. of Obstetrics, Gynecology, and Reproductive Biologyen_US
dc.contributor.corporatenameHarvard Medical Schoolen_US
dc.contributor.corporatenameTexas. Dept. of State Health Servicesen_US
dc.contributor.corporatenameGeorgia Institute of Technology. School of Biologyen_US
dc.contributor.corporatenameBoston University. Dept. of Epidemiologyen_US
dc.contributor.corporatenameMedical Institute (Austin, Texas)en_US
dc.publisher.originalNational Institute of Environmental Health Sciences
dc.identifier.doi10.1289/ehp.8221


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record