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dc.contributor.authorSundquist, Wesleyen_US
dc.date.accessioned2012-02-27T21:21:41Z
dc.date.available2012-02-27T21:21:41Z
dc.date.issued2012-01-31
dc.identifier.urihttp://hdl.handle.net/1853/42959
dc.descriptionWes Sundquist, H.A. and Edna Benning Presidential Endowed Chair, Professor & Co-Chair in the Department of Biochemistry at the University of Utah presented a lecture on Tuesday, January 31, 2012 from 11:00 AM to 12:00 PM in the Klaus Advanced Computing Building, Room 1116E.en_US
dc.descriptionRuntime: 60:33 minutes.en_US
dc.description.abstractThe Endosomal Sorting Complexes Required for Transport (ESCRT) pathway mediates intraluminal endosomal vesicle formation, budding of HIV-1 and other enveloped viruses, and the final abscission step of cytokinesis in mammals and archaea. I will review our current understanding of the roles of different EXCRT factors in HIV budding, and then discuss our recent findings that in addition to their roles in abscission, EXCRT factors are also required for several key steps in mitosis, including creation of the bipolar spindle and proper pairing and segregation of sister chromatids. Our studies indicate that the EXCRT pathway functions at both centrosomes and centromeres during mitosis, and then at midbodies during abscission, thereby helping to ensure ordered progression through the different stages of cell division.en_US
dc.format.extent60:33 minutes
dc.language.isoen_USen
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectHIVen_US
dc.subjectCell divisionen_US
dc.titleThe ESCRT pathway in HIV Budding and Cell Divisionen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameUniversity of Utah. Dept. of Biochemistryen_US


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