Uncovering Metabolic Regulation and Dynamics

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Please use this identifier to cite or link to this item: http://hdl.handle.net/1853/44491

Title: Uncovering Metabolic Regulation and Dynamics
Author: Styczynski, Mark
Abstract: Understanding and controlling cellular metabolism (the process by which nutrients taken into a cell are turned into energy and the building blocks for more cells) is crucial to numerous applications, from enabling more efficient bioenergy production to unraveling the mechanisms of diseases like cancer. However, true understanding of (and control over) metabolism is hindered by a dearth of information available about the dynamics of metabolism and the molecular mechanisms that regulate those dynamics. A deeper understanding in these areas would enable much more efficient manipulation of existing metabolic networks to circumvent or exploit native metabolic regulation. In this seminar, we will discuss our work as we begin to unravel metabolic dynamics and regulation in two different (yet related) systems: yeast and cancer. Using mass spectrometry, we investigate the metabolic dynamics of cancer cells in response to environmental perturbations that we expect tumors to encounter in vivo. We also use complementary high-throughput analytical techniques to begin to enumerate the space of metabolite-protein interactions in the metabolic network of the yeast Saccharomyces cerevisiae.
Description: Presented on July 10, 2012 from 8:30 a.m.-9:30 a.m. at the Parker H. Petit Institute for Bioengineering & Bioscience (IBB), room 1128, Georgia Tech. Runtime: 51:22 minutes
Type: Lecture
URI: http://hdl.handle.net/1853/44491
Date: 2012-07-10
Contributor: Georgia Institute of Technology. Institute for Bioengineering and Bioscience
Georgia Institute of Technology. School of Chemical and Biomolecular Engineering
Relation: Petit Institute Breakfast Club Seminar Series
Publisher: Georgia Institute of Technology
Subject: Metabolomics
Systems biology

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