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dc.contributor.authorSamuel, Aravien_US
dc.date.accessioned2012-12-18T21:09:40Z
dc.date.available2012-12-18T21:09:40Z
dc.date.issued2012-11-19
dc.identifier.urihttp://hdl.handle.net/1853/45595
dc.descriptionPresented on November 19, 2012 from 2 – 3:00 pm in Marcus Nanotechnology Conference room 1116.en_US
dc.descriptionRuntime: 61:30 minutes.en_US
dc.description.abstractDirected locomotion requires coordinated motor activity throughout an animal’s body. The nematode C. elegans, with only 302 neurons, offers an opportunity to understand how locomotion is organized by an entire motor system. We discovered that the mechanism that organizes undulatory locomotion in C. elegans is a novel form of sensory feedback within the motor circuit. Stretch-sensory feedback simply compels each body segment to bend in the same direction and shortly after the bending of the adjacent anterior segment. Remarkably, the entire sensorimotor loop operates is contained within a single (particularly sophisticated) type of neuron. We used microfluidics, optogenetics, calcium imaging, and modeling to show how stretch sensory feedback is integrated into the motor circuit and how it explains the propagation of undulatory waves from head to tail. Our results point to a new framework for the organization of swimming and crawling gaits in worm undulatory locomotion.en_US
dc.format.extent61:30 minutes
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectDirected locomotionen_US
dc.subjectWormsen_US
dc.subjectUndulatory locomotionen_US
dc.titleHow Worms Wiggleen_US
dc.typeLectureen_US
dc.typeVideoen_US
dc.contributor.corporatenameHarvard Universityen_US
dc.contributor.corporatenameGeorgia Institute of Technology. School of Physicsen_US


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