• Login
    View Item 
    •   SMARTech Home
    • Undergraduate Research Opportunities Program (UROP)
    • Undergraduate Research Option Theses
    • View Item
    •   SMARTech Home
    • Undergraduate Research Opportunities Program (UROP)
    • Undergraduate Research Option Theses
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    High-contrast metal-responsive fluorescent probes based on synergistic electronic and conformational switching

    Thumbnail
    View/Open
    sarwar_mysha_2011fall.pdf (668.8Kb)
    Date
    2012-12-18
    Author
    Sarwar, Mysha
    Metadata
    Show full item record
    Abstract
    We have prepared and characterized a Mg(II)-responsive fluorescent probe, constructed using a large tetradentate, 15-membered crown ether ligand and a 1,3,5-triaryl-substituted pyrazoline fluorophore. The photoinduced electron transfer (PET) driving force between the ligand and fluorophore controls the fluorescence contrast ratio when an analyte is bound to the probe. Previous studies have shown that the maximum obtainable fluorescence probes based on macrocyclic ligands was impaired due to ternary complex formation of the metal-ligand complex with the solvent molecules. We redesigned the metal ion receptor by incorporating the aniline ring into the ligand. We selected four fluoro substituents to increase the electron withdrawing ability of the 1-aryl-ring, yielding a very high fluorescence enhancement upon saturation with Mg(II) in acetonitrile. The quantum yield of this pyrazoline probe was found to be 79%.We expect that the described approach should be applicable for rationally designing high-contrast pyrazoline-based PET probes selective towards other metal cations as well.
    URI
    http://hdl.handle.net/1853/45616
    Collections
    • Undergraduate Research Option Theses [631]
    • School of Chemistry and Biochemistry Undergraduate Research Option Theses [46]

    Browse

    All of SMARTechCommunities & CollectionsDatesAuthorsTitlesSubjectsTypesThis CollectionDatesAuthorsTitlesSubjectsTypes

    My SMARTech

    Login

    Statistics

    View Usage StatisticsView Google Analytics Statistics
    • About
    • Terms of Use
    • Contact Us
    • Emergency Information
    • Legal & Privacy Information
    • Accessibility
    • Accountability
    • Accreditation
    • Employment
    • Login
    Georgia Tech

    © Georgia Institute of Technology

    • About
    • Terms of Use
    • Contact Us
    • Emergency Information
    • Legal & Privacy Information
    • Accessibility
    • Accountability
    • Accreditation
    • Employment
    • Login
    Georgia Tech

    © Georgia Institute of Technology