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dc.contributor.authorUehlin, Andrew
dc.date.accessioned2013-02-20T18:30:20Z
dc.date.available2013-02-20T18:30:20Z
dc.date.issued2013-01-22
dc.identifier.urihttp://hdl.handle.net/1853/46223
dc.descriptionAndrew F. Uehlin presented a lecture at the Nano@Tech Meeting on January 22, 2013 at 12 noon in room 1116 of the Marcus Nanotechnology Building.en_US
dc.descriptionAndrew F. Uehlin received his B.S. degree in Biomedical Engineering, and M.S. and Ph.D in Materials Engineering from the University of Alabama at Birmingham (UAB). Dr. Uehlin's research involved polymeric biomaterials, implant-tissue interactions, tissue engineering, and orthopedic bioengineering. His current role is in cardiac rhythm management and electrophysiology in the medical device industry as an agent for St. Jude Medical, Inc, based out of Birmingham, Alabama.
dc.descriptionRuntime: 34:55 minutes
dc.description.abstractThe anterior cruciate ligament (ACL) is the most commonly injured ligament of the knee, often requiring orthopedic reconstruction using autograft or allograph tissue, both with significant disadvantages. As a result, tissue engineering an ACL replacement graft has been heavily investigated. This study attempts to replicate the morphology and mechanical properties of the ACL using a nanomatrix composite of highly-aligned poly(lactic acid) (PLA) fibers with various surface and biochemical modifications. Additionally, this study attempts to recreate the natural mineralization gradient found at the ACL enthesis onto the scaffold, capable of inducing a favorable cellular response in vitro. Furthering the development of the PLA nanomatrix composite, a bioinkjet printer was used to immobilize nanoparticulate hydroxyapatite (HANP) on the surface of the scaffold. The results of studies assessing the proliferation and differentiation response of human mesenchymal stem cells (hMSCs) in vitro with a variety of conditions and combinations of the PLA nanofiber scaffold surface modifications will be presented.en_US
dc.format.extent34:55 minutes
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.relation.ispartofseriesNano@Tech Lecture Series
dc.subjectNanomaterialsen_US
dc.subjectNanotechnologyen_US
dc.subjectOrthopaedic bioengineeringen_US
dc.subjectPolymeric biomaterialsen_US
dc.titleOptimization of a Biomimetic Poly-(Lactic Acid) Ligament Scaffolden_US
dc.typeMoving Image
dc.contributor.corporatenameGeorgia Institute of Technology. Microelectronics Research Centeren_US
dc.contributor.corporatenameGeorgia Institute of Technology. Nanotechnology Research Centeren_US
dc.contributor.corporatenameSt. Jude Medical, Inc.en_US
dc.embargo.termsnullen_US
dc.type.genreLecture


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