Molecular dynamic simulation of mixed lipid bilayer system consisting of phospholipids and lysolipid for enhancement of drug delivery
Park, Jun Seok
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Current medical technology has advanced tremendously over the last century. Nevertheless, the world sits far away from any possible cure for cancer, and available treatments have many obstacles to overcome. Approximately 85% of all cancer patients develop solid tumors, in which half of these cases results in death due to malignant disease. Treatment such as chemotherapy has significant issues in delivering the required dosage of drugs to the cancer site. Large amounts of drugs are required to be injected in order to overcome the circulatory system, however, due to toxicity there is a limitation on administered dosage allowed. To solve this problem, various smart drug delivery systems have been developed for cancer therapy in an attempt to heighten the drug's efficacy. Recently, a promising drug delivery method that utilizes liposomes to specifically target solid tumors has been proposed. A liposome is an artificial lipid vesicle composed of a lipid bilayer that can encapsulate anti-cancer drugs such as Doxorubicin. The overall goal of liposomal drug delivery is to selectively target tumor and other diseased tissues to allow site specific release of such drug with enhanced permeability in combination with local hyperthermia to allow reduction in toxicity by limiting the systemic exposure to critical normal tissues.