Routes to Chiral Purity Involving Crystallization
Rousseau, Ronald W
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Chiral purity has become an increasingly important characteristic of many specialty chemicals, especially pharmaceuticals. Manufacturers seeking chiral purity have two choices: (1) utilize syntheses that directly yield such purity or (2) separate and purify a desired stereoisomer from a mixture containing two or more isomers. This presentation will highlight the use of crystallization in meeting the challenges of such separations. Particular emphasis will be given to the role of nucleation in determining the identity of the species produced and to controlling system conditions so that nucleation and growth mechanisms may be manipulated to influence the process outcome.