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dc.contributor.authorDavis, Michael E.en_US
dc.contributor.authorHsieh, Patrick C.H.en_US
dc.contributor.authorGrodzinsky, Alan J.en_US
dc.contributor.authorLee, Richard T.en_US
dc.date.accessioned2013-06-03T20:16:35Z
dc.date.available2013-06-03T20:16:35Z
dc.date.issued2005-07
dc.identifier.citationDavis M.E., Hsieh P.C.H., Grodzinsky A.J. and Lee R.T., “Custom design of the cardiac microenvironment with biomaterials,” Circulation Research, 97, 1, 8-15 (July 8, 2005)en_US
dc.identifier.issn0009-7330
dc.identifier.urihttp://hdl.handle.net/1853/47158
dc.description© 2005 American Heart Association, Inc. All rights reserved. The electronic version of this article is the complete one and can be found online at: http://circres.ahajournals.org/content/97/1/8en_US
dc.descriptionDOI: 10.1161/01.RES.0000184694.03262.6den_US
dc.description.abstractMany strategies for repairing injured myocardium are under active investigation, with some early encouraging results. These strategies include cell therapies, despite little evidence of long-term survival of exogenous cells, and gene or protein therapies, often with incomplete control of locally-delivered dose of the factor. We propose that, ultimately, successful repair and regeneration strategies will require quantitative control of the myocardial microenvironment. This precision control can be engineered through designed biomaterials that provide quantitative adhesion, growth, or migration signals. Quantitative timed release of factors can be regulated by chemical design to direct cellular differentiation pathways such as angiogenesis and vascular maturation. Smart biomaterials respond to the local environment, such as protease activity or mechanical forces, with controlled release or activation. Most of these new biomaterials provide much greater flexibility for regenerating tissues ex vivo, but emerging technologies like self-assembling nanofibers can now establish intramyocardial cellular microenvironments by injection. This may allow percutaneous cardiac regeneration and repair approaches, or injectable-tissue engineering. Finally, materials can be made to multifunction by providing sequential signals with custom design of differential release kinetics for individual factors. Thus, new rationally-designed biomaterials no longer simply coexist with tissues, but can provide precision bioactive control of the microenvironment that may be required for cardiac regeneration and repair.en_US
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectTissue engineeringen_US
dc.subjectBiomaterialsen_US
dc.subjectRegenerationen_US
dc.subjectMicroenvironmenten_US
dc.titleCustom design of the cardiac microenvironment with biomaterialsen_US
dc.typeArticleen_US
dc.contributor.corporatenameHarvard Medical Schoolen_US
dc.contributor.corporatenameBrigham and Women’s Hospital. Cardiovascular Divisionen_US
dc.publisher.originalAmerican Heart Associationen_US
dc.identifier.doi10.1161/01.RES.0000173376.39447.01


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