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dc.contributor.authorHunt, William D.
dc.contributor.authorStubbs, Desmond D.
dc.contributor.authorLee, Sang-Hun
dc.date.accessioned2013-06-03T20:25:32Z
dc.date.available2013-06-03T20:25:32Z
dc.date.issued2003-06
dc.identifier.citationHunt, William D.; Stubbs, D.D.; and Lee, S.H., "Time-dependent signatures of acoustic wave biosensors," Proceedings of the IEEE, Vol. 91, no.6, pp.890-901 (June 2003).en_US
dc.identifier.issn0018-9219 (print)
dc.identifier.urihttp://hdl.handle.net/1853/47169
dc.description© 2003 IEEE. Personal use of this material is permitted. Permission from IEEE must be obtained for all other uses, in any current or future media, including reprinting/republishing this material for advertising or promotional purposes, creating new collective works, for resale or redistribution to servers or lists, or reuse of any copyrighted component of this work in other works.en_US
dc.descriptionDOI: 10.1109/JPROC.2003.813566
dc.description.abstractAcoustic wave devices coated with a biolayer represent one biosensor approach for the detection of medically relevant biomolecules. In a typical application, the acoustic wave device is connected in an oscillator circuit, and the frequency shift ∆ f resulting from a biomolecular event is recorded. In this paper, we discuss our recent work in this field, which has included the use of Rayleigh wave surface acoustic wave devices for vapor phase detection as well as quartz crystal microbalance devices for liquid phase measurements. For all of the results reported herein the biofilm on the surface of the acoustic wave device consists of a layer of antibodies raised against a specific target molecule or antigen. We present our results for the vapor phase detection of small molecules such as uranine and cocaine as well as liquid phase detection of small and large molecules. The data we present from these various experiments is the signature associated with the biomolecular recognition events; that is, we record and present ∆ f(t). Finally, we present the recent results of our time-dependent perturbation theory work, which gives a potential method for resolving the acoustic wave biosensor signature into information relating to molecular structure changes during a molecular recognition event.en_US
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectAcoustic sensorsen_US
dc.subjectBiosensorsen_US
dc.subjectBulk acoustic waveen_US
dc.subjectQuartz crystal microbalanceen_US
dc.subjectSurface acoustic waveen_US
dc.titleTime-dependent signatures of acoustic wave biosensorsen_US
dc.typeArticleen_US
dc.contributor.corporatenameGeorgia Institute of Technology. Center for Organic Photonics and Electronicsen_US
dc.contributor.corporatenameGeorgia Institute of Technology. School of Chemistry and Biochemistryen_US
dc.contributor.corporatenameGeorgia Institute of Technology. School of Electrical and Computer Engineeringen_US
dc.contributor.corporatenameEmory University. School of Medicineen_US
dc.publisher.originalInstitute of Electrical and Electronics Engineers
dc.identifier.doi10.1109/JPROC.2003.813566
dc.embargo.termsnullen_US


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