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dc.contributor.authorAl-Daghri, Nasser M.en_US
dc.contributor.authorAl-Attas, Omar S.en_US
dc.contributor.authorAlokail, Majed S.en_US
dc.contributor.authorAlkharfy, Khalid M.en_US
dc.contributor.authorYakout, Sobhy M.en_US
dc.contributor.authorSabico, Shaun B.en_US
dc.contributor.authorGibson, Gregen_US
dc.contributor.authorChrousos, George P.en_US
dc.contributor.authorKumar, Sudheshen_US
dc.date.accessioned2013-08-23T19:15:20Z
dc.date.available2013-08-23T19:15:20Z
dc.date.issued2011-04-04
dc.identifier.citationAl-Daghri N.M., Al-Attas O.S., Alokail M.S., Alkharfy K.M., Yakout S.M., et al. (2011) Parent-Offspring Transmission of Adipocytokine Levels and Their Associations with Metabolic Traits. PLoS ONE 6(4): e18182.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/1853/48729
dc.description© 2011 Al-Daghri et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.descriptionDOI: 10.1371/journal.pone.0018182en_US
dc.description.abstractAdipose tissue secreted cytokines (adipocytokines) have significant effects on the physiology and pathology of human metabolism relevant to diabetes and cardiovascular disease. We determined the relationship of the pattern of these circulating hormones with obesity-related phenotypes and whether such pattern is transmitted from parent to offspring. A combined total of 403 individuals from 156 consenting Saudi families divided into initial (119 families with 123 adults and 131 children) and replication (37 families with 58 adults and 91 children) cohorts were randomly selected from the RIYADH Cohort study. Anthropometrics were evaluated and metabolic measures such as fasting serum glucose, lipid profiles, insulin, leptin, adiponectin, resistin, tumor necrosis factor alpha (TNFa), activated plasminogen activator inhibitor 1 (aPAI1), high sensitivity C-reactive protein (hsCRP) and angiotensin II were also assessed. Parent-offspring regressions revealed that with the exception of hsCRP, all hormones measured showed evidence for significant inheritance. Principal component (PC) analysis of standardized hormone levels demonstrated surprising heritability of the three most common axes of variation. PC1, which explained 21% of the variation, was most strongly loaded on levels of leptin, TNFa, insulin, and aPAI1, and inversely with adiponectin. It was significantly associated with body mass index (BMI) and phenotypically stronger in children, and showed a heritability of ,50%, after adjustment for age, gender and generational effects. We conclude that adipocytokines are highly heritable and their pattern of co-variation significantly influences BMI as early as the pre-teen years. Investigation at the genomic scale is required to determine the variants affecting the regulation of the hormones studied.en_US
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectAdipocytokineen_US
dc.subjectDiabetesen_US
dc.subjectCardiovascular diseaseen_US
dc.subjectHuman metabolismen_US
dc.subjectInherited metabolic patternsen_US
dc.titleParent-Offspring Transmission of Adipocytokine Levels and Their Associations with Metabolic Traitsen_US
dc.typeArticleen_US
dc.contributor.corporatenameJāmiʻat al-Malik Saʻūden_US
dc.contributor.corporatenameGeorgia Institute of Technology. Center for Integrative Genomicsen_US
dc.contributor.corporatenameGeorgia Institute of Technology. School of Biologyen_US
dc.contributor.corporatenamePanepistēmio Athēnōnen_US
dc.contributor.corporatenameUniversity of Warwick. Clinical Sciences Research Instituteen_US
dc.publisher.originalPublic Library of Science
dc.identifier.doi10.1371/journal.pone.0018182


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