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dc.contributor.authorYi, Soojinen_US
dc.contributor.authorSummers, Tyrone J.en_US
dc.contributor.authorPearson, Nathaniel M.en_US
dc.contributor.authorLi, Wen-Hsiungen_US
dc.date.accessioned2013-09-19T18:50:58Z
dc.date.available2013-09-19T18:50:58Z
dc.date.issued2004-01
dc.identifier.citationSoojin Yi, Tyrone J. Summers, Nathaniel M. Pearson, and Wen-Hsiung Li, "Recombination has little effect on the rate of sequence divergence in pseudoautosomal boundary 1 among humans and great apes," Genome Research, 2004 Jan;14(1):37-43., 14, 37-43.en_US
dc.identifier.issn1088-9051
dc.identifier.urihttp://hdl.handle.net/1853/49002
dc.description©2004 by Cold Spring Harbor Laboratoryen_US
dc.descriptionDOI: 10.1101/gr.1777204en_US
dc.description.abstractRecent studies indicated that recombination is strongly mutagenic. In particular, data from the mouse pseudoautosomal boundary (PAB) suggested that locally intensive recombination increased the nucleotide substitution rate by more than 100-fold and greatly increased the GC content. Here we study the rates of nucleotide substitution in eight introns of the human and great ape XG gene, which spans the boundary between the pseudoautosomal region 1 (PAR1) and the X-specific region. Contrary to what is expected under the above hypothesis, our sequence data from humans and great apes reveal that the PAR1 introns of XG have actually evolved slightly slower than X-specific introns. Only when a New World monkey was compared with hominoids were the rates slightly increased in the PAR1 introns. In terms of base composition, although the intergenic regions of the human PAR1 show a significant increase of G and C nucleotides, the base composition of the surveyed PAR1 introns is similar to that of the X-specific introns. Direct and indirect evidence indicates that the recombination rate is, indeed, much higher in PAR1 introns than in X-specific introns, and that the present PAB has persisted since the common ancestor of hominoids. Therefore, the mutagenic effect of recombination is far weaker than previously proposed, at least in hominoid PABs.en_US
dc.language.isoen_USen_US
dc.publisherGeorgia Institute of Technologyen_US
dc.subjectSequence divergenceen_US
dc.subjectHuman and great ape XG geneen_US
dc.subjectHominoidsen_US
dc.subjectRecombinationen_US
dc.subjectPseudoautosomal boundary 1en_US
dc.titleRecombination has little effect on the rate of sequence divergence in pseudoautosomal boundary 1 among humans and greaten_US
dc.typeArticleen_US
dc.contributor.corporatenameUniversity of Chicago. Dept. of Ecology and Evolutionen_US
dc.publisher.originalCold Spring Harbor Laboratory Pressen_US
dc.identifier.doi10.1101/gr.1777204


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